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Title:
ANTIVIRAL AGENT INCLUDING TRIAZINOINDOLE DERIVATIVE AS ACTIVE INGREDIENT
Document Type and Number:
WIPO Patent Application WO/2023/277341
Kind Code:
A1
Abstract:
The present invention relates to an antiviral agent including a triazinoindole derivative as an active ingredient. The triazinoindole derivative compound of the present invention inhibits interaction between ACE2 and spike proteins and exhibits excellent antiviral activity against SARS-CoV-2. In addition, the triazinoindole derivative compound of the present invention exhibits excellent effects in assays for metabolic stability (MS) and plasma stability (PS) and very low inhibition rates in CYP450 inhibition assay.

Inventors:
JUNG SE JIN (KR)
LEE JEE-YOUNG (KR)
LIM JI YOUN (KR)
LEE SEUNGJU (KR)
KANG DONGWAN (KR)
LEE HA-YEON (KR)
LEE JI HOON (KR)
KIM SOONG-HYUN (KR)
Application Number:
PCT/KR2022/006850
Publication Date:
January 05, 2023
Filing Date:
May 13, 2022
Export Citation:
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Assignee:
DAEGU GYEONGBUK MEDICAL INNOVATION FOUND (KR)
International Classes:
A61K31/53; A61P31/12; A61P31/14
Foreign References:
US20110218155A12011-09-08
Other References:
UPADHYAY KULDIP; MANVAR ATUL; LODDO ROBERTA; COLLA PAOLO LA; VIRSODIYA VIJAY; TRIVEDI JALPA; CHANIYARA RAVI; SHAH ANAMIK: "Syntheses and in vitro biological screening of 1-aryl-10H-[1,2,4]triazolo[3′,4′:3,4][1,2,4]triazino[5,6-b]indoles", MEDICINAL CHEMISTRY RESEARCH, vol. 22, no. 8, 30 November 2012 (2012-11-30), US , pages 3675 - 3686, XP037914895, ISSN: 1054-2523, DOI: 10.1007/s00044-012-0342-1
ANELISE S. NAZARI FORMAGIO, SANTOS PATRICIA R., ZANOLI KARINE, UEDA-NAKAMURA TANIA, DÜSMAN TONIN LILIAN T., NAKAMURA CELSO V., SAR: "Synthesis and antiviral activity of β-carboline derivatives bearing a substituted carbohydrazide at C-3 against poliovirus and herpes simplex virus (HSV-1)", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 44, no. 11, 1 November 2009 (2009-11-01), pages 4695 - 4701, XP055030414, ISSN: 02235234, DOI: 10.1016/j.ejmech.2009.07.005
YONGXIAN LIU, HONGJIAN SONG, YUANQIONG HUANG, JIARUI LI, SHENG ZHAO, YUCHUAN SONG, PEIWEN YANG, ZHIXIN XIAO, YUXIU LIU, YONGQIANG : "Design, Synthesis, and Antiviral, Fungicidal, and Insecticidal Activities of Tetrahydro-β-carboline-3-carbohydrazide Derivatives", JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, vol. 62, no. 41, 15 October 2014 (2014-10-15), US , pages 9987 - 9999, XP055529273, ISSN: 0021-8561, DOI: 10.1021/jf503794g
DENG, J. ; SANCHEZ, T. ; AL-MAWSAWI, L.Q. ; DAYAM, R. ; YUNES, R.A. ; GAROFALO, A. ; BOLGER, M.B. ; NEAMATI, N.: "Discovery of structurally diverse HIV-1 integrase inhibitors based on a chalcone pharmacophore", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 15, no. 14, 15 July 2007 (2007-07-15), AMSTERDAM, NL, pages 4985 - 5002, XP026265763, ISSN: 0968-0896, DOI: 10.1016/j.bmc.2007.04.041
Attorney, Agent or Firm:
LEE, Won Hee (KR)
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