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Title:
APPLICATION OF BREAST MILK-DERIVED LACTOBACILLUS REUTERI IN LOWERING LIPID AND REGULATING LIPID METABOLISM RHYTHM
Document Type and Number:
WIPO Patent Application WO/2020/228144
Kind Code:
A1
Abstract:
An application of breast milk-derived lactobacillus reuteri in lowering lipid and regulating lipid metabolism rhythm, relating to the fields of microbial technology and food science. The lactobacillus reuteri FN041 can prevent and/or treat lipid metabolism rhythm disorders and has the functions specifically embodied in: (1) significantly reducing weight gain under the influence of high lipid; (2) significantly reducing abnormal increase of peritesticular adipose tissue indexes under the influence of high lipid; (3) significantly reducing hepatic fatty infiltration and abnormal increase of testicular fat cell area under the influence of high lipid; (4) significantly reducing abnormal increase of the content of TG, TC, LDL-C, and HDL-C in serum under the influence of high lipid; (5) significantly reducing abnormal increase of plasma FD4 content in blood and of the content of LPS, LBP, and TNF-α in serum under the influence of high lipid; and (6) restoring the content of triglyceride in serum and the rhythm of the expressions of biological clock genes Clock, Bmal1, and Per2 in a liver under the influence of high lipid.

Inventors:
SUN JIN (CN)
LI SHUANGQI (CN)
QI CE (CN)
Application Number:
PCT/CN2019/098529
Publication Date:
November 19, 2020
Filing Date:
July 31, 2019
Export Citation:
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Assignee:
FINE HUNAN BIOTECHNOLOGY CO LTD (CN)
SUN JIN (CN)
FINE GUANGZHOU BIOTECHNOLOGY CO LTD (CN)
International Classes:
C12N5/10; A61K35/747; A61P3/06; C12N1/20
Domestic Patent References:
WO2009112455A12009-09-17
WO2011060488A12011-05-26
Foreign References:
CN107523526A2017-12-29
CN106399154A2017-02-15
CN108210525A2018-06-29
CN106434427A2017-02-22
CA2662710A12008-03-13
Attorney, Agent or Firm:
HARBIN SHINEIP INTELLECTUAL PROPERTY AGENCY CO., LTD. (CN)
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