Title:
APPLICATION OF CHIGLITAZAR AND RELATED COMPOUNDS THEREOF
Document Type and Number:
WIPO Patent Application WO/2020/063463
Kind Code:
A1
Abstract:
Provided is an application of chiglitazar and related compounds thereof; in vitro models and animal models illustrate that chiglitazar and related compounds thereof inhibit fibroblast activation, matrix production, monocyte activation and chemotactic activity in vitro, and reduce inflammatory activity and tissue fibrosis area in animal models of liver fibrosis. Compared with known similar compounds, sodium chiglitazar shows more significant and different activity characteristics, and has better application potential for treating fibrotic disease.
Inventors:
LU XIANPING (CN)
NING ZHIQIANG (CN)
PAN DESI (CN)
KONG YIDI (CN)
NING ZHIQIANG (CN)
PAN DESI (CN)
KONG YIDI (CN)
Application Number:
PCT/CN2019/106893
Publication Date:
April 02, 2020
Filing Date:
September 20, 2019
Export Citation:
Assignee:
SHENZHEN CHIPSCREEN BIOSCIENCES CO LTD (CN)
International Classes:
A61K31/403; A61P1/16; A61P9/10; A61P11/00; A61P13/12; A61P29/00
Domestic Patent References:
| WO2011002012A1 | 2011-01-06 |
Foreign References:
| CN102056606A | 2011-05-11 | |||
| CN102883721A | 2013-01-16 | |||
| US20170174718A1 | 2017-06-22 | |||
| CN201811114946A | 2018-09-25 |
Other References:
LIVAK ET AL., METHODS, 2001
See also references of EP 3858346A4
See also references of EP 3858346A4
Attorney, Agent or Firm:
SHENPAT INTELLECTUAL PROPERTY AGENCY (CN)
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