Title:
APPLICATION OF HALCINONIDE AND DERIVATIVES THEREOF FOR PREPARING DRUG TREATING AND/OR PREVENTING CEREBROVASCULAR DISEASE
Document Type and Number:
WIPO Patent Application WO/2022/204827
Kind Code:
A1
Abstract:
The present invention relates to the technical field of medicine, and specifically relates to an application of halcinonide and derivatives thereof for preparing a drug treating and/or preventing a cerebrovascular disease. The halcinonide and the derivatives thereof described in the present invention have a structural general formula as represented by formula (I), and a therapeutic effect thereof on ischemic stroke is evaluated by means of an MCAO cerebral ischemia-reperfusion injury animal model. An experiment result shows that halcinonide and the derivatives prednisone and testosterone propionate thereof can significantly improve the neurological deficit score of an animal, and the area of infarction is reduced, same can be used in the treatment of an ischemic stroke, and has good application prospects in clinical practice.
Inventors:
CHEN XINPING (CN)
ZHAO WENYANG (CN)
LIU JINGJING (CN)
LI XIANGXIANG (CN)
ZHAO WENYANG (CN)
LIU JINGJING (CN)
LI XIANGXIANG (CN)
Application Number:
PCT/CN2021/082818
Publication Date:
October 06, 2022
Filing Date:
March 24, 2021
Export Citation:
Assignee:
UNIV LANZHOU (CN)
International Classes:
A61K31/58; A61K31/565; A61K31/566; A61K31/567; A61K31/573; A61P9/10
Domestic Patent References:
| WO2011109711A1 | 2011-09-09 | |||
| WO2002087552A2 | 2002-11-07 |
Other References:
PERSKY REBECCA W., LIU FUDONG, XU YAN, WESTON GILLIAN, LEVY STEPHANIE, ROSELLI CHARLES E., MCCULLOUGH LOUISE D.: "Neonatal Testosterone Exposure Protects Adult Male Rats from Stroke", NEUROENDOCRINOLOGY., S.KARGER, BASEL., CH, vol. 97, no. 3, 1 January 2013 (2013-01-01), CH , pages 271 - 282, XP055974475, ISSN: 0028-3835, DOI: 10.1159/000343804
LIMBOURG, F. P. ET AL.: "Rapid nontranscriptional activation of endothelial nitric oxide synthase mediates increased cerebral blood flow and stroke protection by corticosteroids.", THE JOURNAL OF CLINICAL INVESTIGATION., vol. 110, no. 11, 31 December 2002 (2002-12-31), XP055162497, DOI: 10.1172/JCI15481
SIMRET BERAKI, LILY LITRUS, LIZA SORIANO, MARIE MONBUREAU, LILLIAN K. TO, STEVEN P. BRAITHWAITE, KAROLY NIKOLICH, ROMAN URFER, DON: "A Pharmacological Screening Approach for Discovery of Neuroprotective Compounds in Ischemic Stroke", PLOS ONE, vol. 8, no. 7, pages e69233, XP055106884, DOI: 10.1371/journal.pone.0069233
SONG XI, WANG CHANG-LAI,ZHANG ZHENG,QIN HAI-DONG,SHEN HUA,BAO LEI: "Protective Effect of Methylprednisolone on Brain Ischemia-reperfusion Injury in Rats", PRACTICAL GERIATRICS, JIANGSU INSTITUTE OF GERIATRICS, CN, vol. 23, no. 1, 28 February 2009 (2009-02-28), CN , pages 52 - 55, XP055974477, ISSN: 1003-9198, DOI: 10.3969/j.issn.1003-9198.2009.01.016
LIMBOURG, F. P. ET AL.: "Rapid nontranscriptional activation of endothelial nitric oxide synthase mediates increased cerebral blood flow and stroke protection by corticosteroids.", THE JOURNAL OF CLINICAL INVESTIGATION., vol. 110, no. 11, 31 December 2002 (2002-12-31), XP055162497, DOI: 10.1172/JCI15481
SIMRET BERAKI, LILY LITRUS, LIZA SORIANO, MARIE MONBUREAU, LILLIAN K. TO, STEVEN P. BRAITHWAITE, KAROLY NIKOLICH, ROMAN URFER, DON: "A Pharmacological Screening Approach for Discovery of Neuroprotective Compounds in Ischemic Stroke", PLOS ONE, vol. 8, no. 7, pages e69233, XP055106884, DOI: 10.1371/journal.pone.0069233
SONG XI, WANG CHANG-LAI,ZHANG ZHENG,QIN HAI-DONG,SHEN HUA,BAO LEI: "Protective Effect of Methylprednisolone on Brain Ischemia-reperfusion Injury in Rats", PRACTICAL GERIATRICS, JIANGSU INSTITUTE OF GERIATRICS, CN, vol. 23, no. 1, 28 February 2009 (2009-02-28), CN , pages 52 - 55, XP055974477, ISSN: 1003-9198, DOI: 10.3969/j.issn.1003-9198.2009.01.016
Attorney, Agent or Firm:
BEIJING POWER PATENT AGENCY FIRM (CN)
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