Title:
APPLICATION OF MICROORGANISM-DERIVED PLASMALOGEN IN TREATMENT OF COLON CANCER
Document Type and Number:
WIPO Patent Application WO/2022/237632
Kind Code:
A1
Abstract:
The present invention relates to the technical field of biological medicines and microorganisms. Disclosed is an application of microorganism-derived plasmalogen in treatment of colon cancer. The microorganism-derived plasmalogen provided in the present invention is extracted from any one or more of anaerobic microbes of lactobacillus, bifidobacterium, clostridium butyricum and peptostreptococcus after fermentation. The microorganism-derived plasmalogen can reduce the expression of colon cancer related cytokines from a molecular level, inhibit proliferation of colon cancer cells, and reduce the number and volume of colonic adenomas of a colon cancer patient.
Inventors:
LIU YUANFA (CN)
LIU YANJUN (CN)
XU YONGJIANG (CN)
LIU YANJUN (CN)
XU YONGJIANG (CN)
Application Number:
PCT/CN2022/091105
Publication Date:
November 17, 2022
Filing Date:
May 06, 2022
Export Citation:
Assignee:
UNIV JIANGNAN (CN)
International Classes:
A61K31/685; A61P35/00
Foreign References:
| CN113244246A | 2021-08-13 | |||
| CN101675337A | 2010-03-17 | |||
| CN1724544A | 2006-01-25 |
Other References:
"Master Thesis", 1 June 2004, LIAONING NORMAL UNIVERSITY, CN, article YAOYAO ZHAN: "The Extraction of Plasmalogens and the Roles of Plasmalogens in Anti-tumor", pages: 1 - 57, XP093003259
CANQUN LU, CAI ZHENCHAO: "The Biological Function and Metabolism of Plasmalogen", CHEMISTRY OF LIFE : COMMUNICATIONS OF THE CHINESE BIOCHEMICAL SOCIETY, SHANGHAI : ZHONGGUO SHENGWU HUAXUEHUI, CN, vol. 14, no. 6, 1 January 1994 (1994-01-01), CN , pages 33 - 34, XP093003345, ISSN: 1000-1336
JIA DAN, LIU CUI-PING, ZOU WEI: "Functions of Plasmalogen and Their Signal Transduction Mechanism", NATURAL PRODUCT RESEARCH AND DEVELOPMENT, GAI KAN BIANJIBU, CHENGDU, CN, vol. 19, no. 3, 15 June 2007 (2007-06-15), CN , pages 541 - 544, XP093003346, ISSN: 1001-6880, DOI: 10.16333/j.1001-6880.2007.03.043
SHI XU-HUI, RUAN CHANG-QING: "Research advance on preparation and biology function of plasmalogen", CEREALS & OILS, CN, no. 12, 10 December 2008 (2008-12-10), CN , pages 8 - 9, XP055782211, ISSN: 1008-9578
HONG YANG: "Advances in Research on Biological Effects of Plasmalogens", ACTA ACADEMIAE MEDICINAE WANNAN, WANNAN MEDICAL COLLEGE, CN, vol. 21, no. 4, 30 December 2002 (2002-12-30), CN , pages 309 - 311, XP093003347, ISSN: 1002-0217
CANQUN LU, CAI ZHENCHAO: "The Biological Function and Metabolism of Plasmalogen", CHEMISTRY OF LIFE : COMMUNICATIONS OF THE CHINESE BIOCHEMICAL SOCIETY, SHANGHAI : ZHONGGUO SHENGWU HUAXUEHUI, CN, vol. 14, no. 6, 1 January 1994 (1994-01-01), CN , pages 33 - 34, XP093003345, ISSN: 1000-1336
JIA DAN, LIU CUI-PING, ZOU WEI: "Functions of Plasmalogen and Their Signal Transduction Mechanism", NATURAL PRODUCT RESEARCH AND DEVELOPMENT, GAI KAN BIANJIBU, CHENGDU, CN, vol. 19, no. 3, 15 June 2007 (2007-06-15), CN , pages 541 - 544, XP093003346, ISSN: 1001-6880, DOI: 10.16333/j.1001-6880.2007.03.043
SHI XU-HUI, RUAN CHANG-QING: "Research advance on preparation and biology function of plasmalogen", CEREALS & OILS, CN, no. 12, 10 December 2008 (2008-12-10), CN , pages 8 - 9, XP055782211, ISSN: 1008-9578
HONG YANG: "Advances in Research on Biological Effects of Plasmalogens", ACTA ACADEMIAE MEDICINAE WANNAN, WANNAN MEDICAL COLLEGE, CN, vol. 21, no. 4, 30 December 2002 (2002-12-30), CN , pages 309 - 311, XP093003347, ISSN: 1002-0217
Attorney, Agent or Firm:
HARBIN SHINEIP INTELLECTUAL PROPERTY AGENCY CO., LTD. (CN)
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