Title:
APPLICATION OF SERUM PROTEIN HFREP1 IN DIAGNOSIS OF RHEUMATOID ARTHRITIS DISEASE STATE
Document Type and Number:
WIPO Patent Application WO/2021/120827
Kind Code:
A1
Abstract:
Provided is an application of a serum protein HFREP1 in the diagnosis of rheumatoid arthritis disease state. According to DAS28, a rheumatoid arthritis (RA) disease activity scoring system recommended by the European Anti-Rheumatism Alliance, the RA disease state is divided into an active phase and a remission phase. However, the DAS28 scoring system is a set of subjective scoring system, which requires high doctor experience. The serum protein HFREP1 has an extremely high diagnostic significance in the diagnosis and classification of rheumatoid arthritis in the active and remission phases, has high diagnosis accuracy. Compared with the existing DAS28 scoring system, the serum protein HFREP1 is objective and easy to operate, and can be used to prepare a diagnostic kit for the diagnosis and classification of rheumatoid arthritis in the active and remission phases.
Inventors:
LIU SHIJIA (CN)
ZHOU WEI (CN)
JI WEI (CN)
TAN WENFENG (CN)
GUO YUNKE (CN)
KE MENGYING (CN)
LU JIAWEI (CN)
ZHOU WEI (CN)
JI WEI (CN)
TAN WENFENG (CN)
GUO YUNKE (CN)
KE MENGYING (CN)
LU JIAWEI (CN)
Application Number:
PCT/CN2020/122351
Publication Date:
June 24, 2021
Filing Date:
October 21, 2020
Export Citation:
Assignee:
JIANGSU PRECISE MEDICAL TECH CO LTD (CN)
International Classes:
G01N33/68
Foreign References:
| CN110954702A | 2020-04-03 | |||
| CN109959787A | 2019-07-02 | |||
| CN110283754A | 2019-09-27 | |||
| CN201911322787A | 2019-12-20 |
Other References:
RAYBIOTECH, INC.: "Human HFREP1 ELISA", RAYBIOTECH, 19 December 2019 (2019-12-19), pages 1 - 3, XP055822905, Retrieved from the Internet
WU HUNG-TSUNG; OU HORNG-YIH; HUNG HAO-CHANG; SU YU-CHU; LU FENG-HWA; WU JIN-SHANG; YANG YI-CHING; WU CHAO-LIANG; CHANG CHIH-JEN: "A novel hepatokine, HFREP1, plays a crucial role in the development of insulin resistance and type 2 diabetes", DIABETOLOGIA, SPRINGER, vol. 59, no. 8, 25 May 2016 (2016-05-25), BERLIN, DE, pages 1732 - 1742, XP036243888, ISSN: 0012-186X, DOI: 10.1007/s00125-016-3991-7
HOU, CHUNJIANG : "Electrophoresis of serum proteins of rheumatoid arthritis", CONTEMPORARY MEDICINE, vol. 14, no. 23, 5 December 2008 (2008-12-05), pages 55 - 56, XP009528628, ISSN: 1009-4393
PAN, XIAOFU ET AL.: "Identification of Diagnostic Biomarkers for Rheumatoid Arthritis by Proteomic Fingerprinting of Serum", IMMUNOLOGICAL JOURNAL, vol. 25, no. 5, 15 September 2009 (2009-09-15), pages 563 - 567,571, XP055822912, ISSN: 1000-8861
See also references of EP 3929588A4
WU HUNG-TSUNG; OU HORNG-YIH; HUNG HAO-CHANG; SU YU-CHU; LU FENG-HWA; WU JIN-SHANG; YANG YI-CHING; WU CHAO-LIANG; CHANG CHIH-JEN: "A novel hepatokine, HFREP1, plays a crucial role in the development of insulin resistance and type 2 diabetes", DIABETOLOGIA, SPRINGER, vol. 59, no. 8, 25 May 2016 (2016-05-25), BERLIN, DE, pages 1732 - 1742, XP036243888, ISSN: 0012-186X, DOI: 10.1007/s00125-016-3991-7
HOU, CHUNJIANG : "Electrophoresis of serum proteins of rheumatoid arthritis", CONTEMPORARY MEDICINE, vol. 14, no. 23, 5 December 2008 (2008-12-05), pages 55 - 56, XP009528628, ISSN: 1009-4393
PAN, XIAOFU ET AL.: "Identification of Diagnostic Biomarkers for Rheumatoid Arthritis by Proteomic Fingerprinting of Serum", IMMUNOLOGICAL JOURNAL, vol. 25, no. 5, 15 September 2009 (2009-09-15), pages 563 - 567,571, XP055822912, ISSN: 1000-8861
See also references of EP 3929588A4
Attorney, Agent or Firm:
UNITALEN ATTORNEYS AT LAW (CN)
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