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Title:
APPLICATION OF SMALL MOLECULE COMPOUND OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF IN PREPARATION OF ANTI-TUMOR METASTASIS DRUG
Document Type and Number:
WIPO Patent Application WO/2020/244253
Kind Code:
A1
Abstract:
Disclosed is an application of a small molecule compound or a pharmaceutically acceptable salt thereof in the preparation of an anti-tumor metastasis drug. The structure of the compound is as shown in formula (I). The small molecule compound or the pharmaceutically acceptable salt thereof can significantly inhibit the invasion, migration and horizontal movement ability of tumor cells in vitro; moreover, the small molecule compound or the pharmaceutically acceptable salt thereof has low cell cytotoxicity, high safety to normal cells, and good drug-making properties, and can be prepared into an anti-tumor drug and/or an anti-tumor metastasis drug for application to prevent and treat the metastasis of tumor cells in patients with a median or late-stage malignant tumor; in addition, the small molecule compound or the pharmaceutically acceptable salt thereof has a simple structure, is easy to synthesize, can be prepared by large-scale industrial production, and is easy to popularize and apply.

Inventors:
YAN DAOGUANG (CN)
ZHONG WENBIN (CN)
XU MENGYANG (CN)
Application Number:
PCT/CN2020/076031
Publication Date:
December 10, 2020
Filing Date:
February 20, 2020
Export Citation:
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Assignee:
UNIV JINAN (CN)
International Classes:
A61K31/4375; A61K31/403; A61K31/7056; A61K31/706; A61P35/04; C07D209/94; C07D471/04; C07D471/14; C07H15/26; C07H17/02
Domestic Patent References:
WO2009024190A12009-02-26
Foreign References:
CN110464722A2019-11-19
CN1960725A2007-05-09
US5166204A1992-11-24
Other References:
NILS SUNDER-PLASSMANN ET AL.: "Synthesis and Biological Evaluation of New Tetrahydro-B-carbolines as Inhibitors of the Mitotic Kinesin Eg5", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 13, 31 December 2005 (2005-12-31), XP027638201, DOI: 20200517223659X
Attorney, Agent or Firm:
JIAQUAN IP LAW FIRM (CN)
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