Title:
APPLICATIONS OF PTBP1 INHIBITOR IN PREVENTING AND/OR TREATING RETINAL DISEASES
Document Type and Number:
WIPO Patent Application WO/2021/081826
Kind Code:
A1
Abstract:
Disclosed are applications of a PTBP1 inhibitor in preventing and/or treating retinal diseases. Specifically, provided are uses of an inhibitor of PTBP1 gene or an encoded protein thereof, for use in preparing a composition or preparation. The composition or preparation is used for preventing and/or treating the retinal diseases. The present invention, by inhibiting the expression or activity of PTBP1 gene or the encoded protein thereof of the MG cells in the retina, effectively induces the differentiation of the MG cells towards the RGC cells, thus preventing and/or treating the retinal diseases.
Inventors:
YANG HUI (CN)
ZHOU HAIBO (CN)
ZHOU HAIBO (CN)
Application Number:
PCT/CN2019/114447
Publication Date:
May 06, 2021
Filing Date:
October 30, 2019
Export Citation:
Assignee:
CENTER FOR EXCELLENCE IN BRAIN SCIENCE AND INTELLIGENCE TECH CHINESE ACADEMY OF SCIENCES (CN)
International Classes:
C12N15/00; A61K48/00; A61P27/02
Domestic Patent References:
| WO2019204828A1 | 2019-10-24 |
Foreign References:
| CN110257420A | 2019-09-20 |
Other References:
WOHL STEFANIE GABRIELE, REH THOMAS ANDREW: "miR-124-9-9* potentiates Ascl1-induced reprogramming of cultured Müller glia : miRNAs in Glial Reprogramming", GLIA, WILEY-LISS, INC., US, vol. 64, no. 5, 1 May 2016 (2016-05-01), US, pages 743 - 762, XP055782144, ISSN: 0894-1491, DOI: 10.1002/glia.22958
WOHL STEFANIE GABRIELE, REH THOMAS ANDREW: "miR-124-9-9* potentiates Ascl1-induced reprogramming of cultured Müller glia : miRNAs in Glial Reprogramming", GLIA, WILEY-LISS, INC., US, vol. 64, no. 5, 1 May 2016 (2016-05-01), US, pages 743 - 762, XP055782144, ISSN: 0894-1491, DOI: 10.1002/glia.22958
QI XIN: "The role of miR-9 during neuron differentiation of mouse retinal stem cells", ARTIFICIAL CELLS, NANOMEDICINE AND BIOTECHNOLOGY, TAYLOR & FRANCIS INC., US, vol. 44, no. 8, 16 November 2016 (2016-11-16), US, pages 1883 - 1890, XP055808379, ISSN: 2169-1401, DOI: 10.3109/21691401.2015.1111231
WOHL STEFANIE GABRIELE, REH THOMAS ANDREW: "miR-124-9-9* potentiates Ascl1-induced reprogramming of cultured Müller glia : miRNAs in Glial Reprogramming", GLIA, WILEY-LISS, INC., US, vol. 64, no. 5, 1 May 2016 (2016-05-01), US, pages 743 - 762, XP055782144, ISSN: 0894-1491, DOI: 10.1002/glia.22958
QI XIN: "The role of miR-9 during neuron differentiation of mouse retinal stem cells", ARTIFICIAL CELLS, NANOMEDICINE AND BIOTECHNOLOGY, TAYLOR & FRANCIS INC., US, vol. 44, no. 8, 16 November 2016 (2016-11-16), US, pages 1883 - 1890, XP055808379, ISSN: 2169-1401, DOI: 10.3109/21691401.2015.1111231
Attorney, Agent or Firm:
XU & PARTNERS, LLC. (CN)
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