Title:
AQUEOUS PHARMACEUTICAL COMPOSITION CONTAINING FUSION PROTEIN OF SERUM ALBUMIN AND GROWTH HORMONE
Document Type and Number:
WIPO Patent Application WO/2021/085518
Kind Code:
A1
Abstract:
The present invention discloses an aqueous pharmaceutical composition containing a protein in which serum albumin and growth hormone are linked. The aqueous pharmaceutical composition contains, as an active ingredient, a fusion protein of human serum albumin and human growth hormone; the concentration of the fusion protein is 10-100 mg/mL; the concentration of sucrose is 10-150 mg/mL; the concentration of a nonionic surfactant is 0.15-10 mg/mL; the concentration of a preservative is 0.5-12 mg/mL; the concentration of a buffer is 1-30 mM; and the pH is 5.0-8.0.
Inventors:
OKABE SHINJI (JP)
YAMAGUCHI YUKA (JP)
YASUKAWA HIDEHITO (JP)
YAMAGUCHI YUKA (JP)
YASUKAWA HIDEHITO (JP)
Application Number:
PCT/JP2020/040560
Publication Date:
May 06, 2021
Filing Date:
October 29, 2020
Export Citation:
Assignee:
JAPAN CHEM RES (JP)
International Classes:
A61K38/27; A61K9/08; A61K47/04; A61K47/10; A61K47/26; A61K47/64; A61P5/06; C07K14/61; C07K14/765; C07K19/00; C12N15/14; C12N15/18; C12N15/62
Domestic Patent References:
| WO2017159540A1 | 2017-09-21 | |||
| WO2017154869A1 | 2017-09-14 | |||
| WO2017159540A1 | 2017-09-21 | |||
| WO2012063799A1 | 2012-05-18 | |||
| WO2013161958A1 | 2013-10-31 |
Foreign References:
| JP2000502901A | 2000-03-14 | |||
| JP2019500390A | 2019-01-10 | |||
| JP2003530838A | 2003-10-21 | |||
| JP2005514060A | 2005-05-19 | |||
| JP2000502901A | 2000-03-14 | |||
| JP2008518615A | 2008-06-05 | |||
| JP2013501036A | 2013-01-10 | |||
| JP2013518038A | 2013-05-20 |
Other References:
ALTSCHUL SF, J MOL. BIOL., vol. 215, 1990, pages 403 - 10
PEARSONLIPMAN, PROC. NATL. ACAD. SCI., USA, vol. 85, 1988, pages 2444
SMITH, WATERMAN, APPL. MATH., vol. 2, 1981, pages 482 - 9
SMITHWATERMAN, ADV. APPL. MATH., vol. 2, 1981, pages 482 - 9
See also references of EP 4059512A4
PEARSONLIPMAN, PROC. NATL. ACAD. SCI., USA, vol. 85, 1988, pages 2444
SMITH, WATERMAN, APPL. MATH., vol. 2, 1981, pages 482 - 9
SMITHWATERMAN, ADV. APPL. MATH., vol. 2, 1981, pages 482 - 9
See also references of EP 4059512A4
Attorney, Agent or Firm:
YAMAMOTO, Yoshiki (JP)
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