ARALKYL FORMYL-ALKYL PIPERAZINE DERIVATIVES AND THEIR USES AS CEREBRAL NERVE PROTECTIVE AGENT

Title:

ARALKYL FORMYL-ALKYL PIPERAZINE DERIVATIVES AND THEIR USES AS CEREBRAL NERVE PROTECTIVE AGENT

Document Type and Number:

WIPO Patent Application WO2003095437

Kind Code:

A8

Abstract:

The invention relates to aralkyl formyl-alkyl piperazine derivatives, and the use of its compositions in the manufacture of medicaments for preventing or treating cerebral ischemic apoplexy and nerve protection, acting as central system excitable amino acid (N-methy-D-aspartic acid) antagonists (NMDA). The pharmacological experiments show that they display favorable full or ischemic anti-apoplexy activity, nerve protective activity and low side effects.

Inventors:

LI JIANQI (CN)
HUANG LIYING (CN)
MIN YANG (CN)
WENG ZHIJIE (CN)
ZHANG CHUNNIAN (CN)

Application Number:

PCT/CN2003/000273

Publication Date:

February 12, 2004

Filing Date:

April 16, 2003

Export Citation:

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Assignee:

SHANGHAI INST PHARM INDUSTRY (CN)
LI JIANQI (CN)
HUANG LIYING (CN)
MIN YANG (CN)
WENG ZHIJIE (CN)
ZHANG CHUNNIAN (CN)

International Classes:

A61K31/495; A61P25/24; C07D295/192; C07D317/54; (IPC1-7): C07D295/084; C07D295/108; C07D295/192; C07D213/36; C07D215/12; C07D309/36; C07D401/12; C07D405/12; A61K31/495; A61P25/24

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