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Title:
ARBEKACIN DERIVATIVE AND PRODUCTION AND USE OF SAME
Document Type and Number:
WIPO Patent Application WO/2014/192848
Kind Code:
A1
Abstract:
 It was discovered that an arbekacin derivative containing arbekacin carbonate and a carbamate of arbekacin can be produced by adding carbon dioxide or the like to a solution containing arbekacin free base. It was also discovered that this arbekacin derivative has high stability, and that high-purity arbekacin free base and pharmaceutically acceptable salts thereof can be efficiently produced by using this arbekacin derivative.

Inventors:
MIWA HIROYASU (JP)
KISHI HISASHI (JP)
SASAKI TOSHIRO (JP)
MURATA TAKASHI (JP)
OYAMA MAKOTO (JP)
SANO NAO (JP)
ODAGIRI AYAKO (JP)
Application Number:
PCT/JP2014/064221
Publication Date:
December 04, 2014
Filing Date:
May 29, 2014
Export Citation:
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Assignee:
MEIJI SEIKA PHARMA CO LTD (JP)
International Classes:
C07H15/236; C07H15/26; A61K31/7048; A61P11/00; A61P31/04
Domestic Patent References:
WO2005070945A12005-08-04
WO2007142150A12007-12-13
Foreign References:
JPS5233629B21977-08-30
JPH09104694A1997-04-22
JPS5233629B21977-08-30
JPS6332799B21988-07-01
Other References:
KONDO SHINICHI: "Development of arbekacin and synthesis of new derivatives stable to enzymic modifications by methicillin-resistant Staphylococcus aureus", JAPANESE JOURNAL OF ANTIBIOTICS, vol. 47, no. 6, 1 June 1994 (1994-06-01), pages 561 - 574, XP055296772
KONDO SHINICHI ET AL.: "Synthesis of 2''-amino- 2''-deoxyarbekacin and its analogs having potent activity against methicillin-resistant Staphylococcus aureus", JOURNAL OF ANTIBIOTICS, vol. 47, no. 7, 2 March 1994 (1994-03-02), pages 821 - 832, XP055296776
KONDO SHINICHI ET AL.: "Structures of enzymically modified products of arbekacin by methicillin-resistant Staphylococcus aureus", JOURNAL OF ANTIBIOTICS, vol. 46, no. 2, 1 January 1993 (1993-01-01), pages 310 - 315, XP055131053, DOI: 10.7164/ANTIBIOTICS.46.310
HOTTA KUNIMOTO ET AL.: "The novel enzymic 3''-N- acetylation of arbekacin by an aminoglycoside 3-N-acetyltransferase of Streptomyces origin and the resulting activity", JOURNAL OF ANTIBIOTICS, vol. 51, no. 8, 19 May 1998 (1998-05-19), pages 735 - 742, XP055296785
HIRAIWA YUKIKO ET AL.: "Synthesis and antibacterial activity of 5-deoxy-5-epi- substituted arbekacin derivatives", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 17, no. 13, 2007, pages 3540 - 3543, XP022114535, DOI: 10.1016/J.BMCL.2007.04.065
See also references of EP 3006451A4
THE JOURNAL OF ANTIBIOTICS, vol. 26, 1973, pages 412
JOURNAL OF SYNTHETIC ORGANIC CHEMISTRY, vol. 57, no. 5, 1999, pages 368 - 373
Attorney, Agent or Firm:
CENTCREST IP ATTORNEYS (JP)
Patent business corporation cent Crest international patent firm (JP)
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