Title:
AROMATIC CARBOXYLIC ACID DERIVATIVES FOR TREATMENT AND PROPHYLAXIS OF GASTROINTESTINAL DISEASES INCLUDING COLON CANCER
Document Type and Number:
WIPO Patent Application WO/2010/030781
Kind Code:
A3
Abstract:
Prodrug compounds which metabolize into 5-ASA or analogs thereof, and taurine or analogs thereof, in the colon site are disclosed. Pharmaceutical compositions including the compounds, and methods of treatment using the compounds, are also disclosed. Such compounds have utility for treating or preventing gastrointestinal disorders, including colon cancer, ulcerative colitis and Crohn's disease.
Inventors:
EKWURIBE NNOCHIRI (US)
Application Number:
PCT/US2009/056515
Publication Date:
October 14, 2010
Filing Date:
September 10, 2009
Export Citation:
Assignee:
NUMED INTERNATIONAL INC (US)
EKWURIBE NNOCHIRI (US)
EKWURIBE NNOCHIRI (US)
International Classes:
C07C311/45; A61K31/18; A61K31/185; A61P1/04; A61P35/00; C07C245/08; C07C309/26; C07D311/36; C07D311/58
Domestic Patent References:
| WO2006125295A1 | 2006-11-30 |
Foreign References:
| US20070197479A1 | 2007-08-23 |
Other References:
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 17, no. 7, 2007, pages 1897 - 1902
Attorney, Agent or Firm:
BRADIN, David, S. (P.O. Box 14329Research Triangle Park, NC, US)
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