Title:
ARYL GLUCOSIDE DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/2021/227439
Kind Code:
A1
Abstract:
Provided in the present invention are a compound for inhibiting sodium glucose cotransporter 1, and a pharmaceutically acceptable salt and a stereoisomer of the compound. The compound is used for a pharmaceutical composition, and further provided is a method for preparing and using same, comprising the use of the drug or the composition for the treatment and amelioration of diabetes, and in the treatment of cardiovascular and cerebrovascular diseases, body weight reduction, fatty liver, constipation, metabolism-related diseases and tumors.
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Inventors:
WANG HAIBO (CN)
DU FENGTIAN (CN)
ZHANG QIANG (CN)
DU FENGTIAN (CN)
ZHANG QIANG (CN)
Application Number:
PCT/CN2020/131248
Publication Date:
November 18, 2021
Filing Date:
November 24, 2020
Export Citation:
Assignee:
SHANGHAI ZHEYE BIOTECHNOLOGY CO LTD (CN)
International Classes:
A61K31/351; C07D309/10; A61P1/00; A61P3/10; A61P9/00; A61P35/00; C07H5/00
Domestic Patent References:
| WO2020068661A1 | 2020-04-02 |
Foreign References:
| CN110092768A | 2019-08-06 | |||
| CN104854096A | 2015-08-19 | |||
| CN102414191A | 2012-04-11 | |||
| CN108610385A | 2018-10-02 | |||
| CN110066302A | 2019-07-30 |
Other References:
DATABASE REGISTRY 19 June 2014 (2014-06-19), ANONYMOUS : " Benzenebutanamide, N-[2-[[2-(dimethylamino)ethyl]amino]-1,1-dimethyl-2- oxoethyl]-4-[[2-methyl-5-[(5R)-5-C-(methylsulfonyl)-.beta.-Dxylopyranosyl]phenyl]methyl]- (CA INDEX NAME) ", XP055866032, retrieved from STN Database accession no. 1610955-64-0
LAUREN E. SIROIS, MATTHEW M. ZHAO, NGIAP-KIE LIM, MARK S. BEDNARZ, BRYCE A. HARRISON, WENXUE WU: "Process Development for a Locally Acting SGLT1 Inhibitor, LX2761, Utilizing sp 3 –sp 2 Suzuki Coupling of a Benzyl Carbonate", ORGANIC PROCESS RESEARCH & DEVELOPMENT, AMERICAN CHEMICAL SOCIETY, US, vol. 23, no. 1, 18 January 2019 (2019-01-18), US , pages 45 - 61, XP055636549, ISSN: 1083-6160, DOI: 10.1021/acs.oprd.8b00325
NICOLE C. GOODWIN, ZHI-MING DING, BRYCE A. HARRISON, ERIC D. STROBEL, ANGELA L. HARRIS, MELINDA SMITH, ANDREA Y. THOMPSON, WENDY X: "Discovery of LX2761, a Sodium-Dependent Glucose Cotransporter 1 (SGLT1) Inhibitor Restricted to the Intestinal Lumen, for the Treatment of Diabetes", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 60, no. 2, 26 January 2017 (2017-01-26), US , pages 710 - 721, XP055636395, ISSN: 0022-2623, DOI: 10.1021/acs.jmedchem.6b01541
REFERENCE JOURNAL OF MEDICINAL CHEMISTRY, vol. 60, 2017, pages 710 - 721
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 136, no. 20, 2014, pages 7205 - 7208
CHEMISTRY - A EUROPEAN JOURNAL, vol. 17, no. 12, 2011, pages 3326 - 3331
JOURNAL OF FLUORESCENCE, vol. 23, no. 1, 2013, pages 181 - 186
JOURNAL OF ORGANIC CHEMISTRY, vol. 76, no. 12, 2011, pages 4964 - 4972
ANGEWANDTE CHEMIE, INTERNATIONAL EDITION, vol. 58, no. 21, 2019, pages 6987 - 6992
CHEMISCHE BERICHTE, vol. 118, no. 4, 1985, pages 1564 - 1574
SCIENCE OF SYNTHESIS, vol. 41, 2010, pages 543 - 612
NATURE, vol. 574, no. 7776, 2019, pages 86 - 89
JOURNAL OF MEDICINAL CHEMISTRY, vol. 60, 2017, pages 710 - 721
ACTA PHARMACEUTICA SINICA, vol. 52, no. 6, 2017, pages 897 - 903
NATURE PROTOCOLS, vol. 2, no. 3, 2007, pages 753 - 762
JOURNAL OF BIOCHEMICAL AND BIOPHYSICAL METHODS, vol. 64, no. 3, 2005, pages 207 - 215
DIABETES TECHNOLOGY & THERAPEUTICS, vol. 13, no. 7, 2011, pages 743 - 775
CAS , no. 186689-07-6
LAUREN E. SIROIS, MATTHEW M. ZHAO, NGIAP-KIE LIM, MARK S. BEDNARZ, BRYCE A. HARRISON, WENXUE WU: "Process Development for a Locally Acting SGLT1 Inhibitor, LX2761, Utilizing sp 3 –sp 2 Suzuki Coupling of a Benzyl Carbonate", ORGANIC PROCESS RESEARCH & DEVELOPMENT, AMERICAN CHEMICAL SOCIETY, US, vol. 23, no. 1, 18 January 2019 (2019-01-18), US , pages 45 - 61, XP055636549, ISSN: 1083-6160, DOI: 10.1021/acs.oprd.8b00325
NICOLE C. GOODWIN, ZHI-MING DING, BRYCE A. HARRISON, ERIC D. STROBEL, ANGELA L. HARRIS, MELINDA SMITH, ANDREA Y. THOMPSON, WENDY X: "Discovery of LX2761, a Sodium-Dependent Glucose Cotransporter 1 (SGLT1) Inhibitor Restricted to the Intestinal Lumen, for the Treatment of Diabetes", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 60, no. 2, 26 January 2017 (2017-01-26), US , pages 710 - 721, XP055636395, ISSN: 0022-2623, DOI: 10.1021/acs.jmedchem.6b01541
REFERENCE JOURNAL OF MEDICINAL CHEMISTRY, vol. 60, 2017, pages 710 - 721
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 136, no. 20, 2014, pages 7205 - 7208
CHEMISTRY - A EUROPEAN JOURNAL, vol. 17, no. 12, 2011, pages 3326 - 3331
JOURNAL OF FLUORESCENCE, vol. 23, no. 1, 2013, pages 181 - 186
JOURNAL OF ORGANIC CHEMISTRY, vol. 76, no. 12, 2011, pages 4964 - 4972
ANGEWANDTE CHEMIE, INTERNATIONAL EDITION, vol. 58, no. 21, 2019, pages 6987 - 6992
CHEMISCHE BERICHTE, vol. 118, no. 4, 1985, pages 1564 - 1574
SCIENCE OF SYNTHESIS, vol. 41, 2010, pages 543 - 612
NATURE, vol. 574, no. 7776, 2019, pages 86 - 89
JOURNAL OF MEDICINAL CHEMISTRY, vol. 60, 2017, pages 710 - 721
ACTA PHARMACEUTICA SINICA, vol. 52, no. 6, 2017, pages 897 - 903
NATURE PROTOCOLS, vol. 2, no. 3, 2007, pages 753 - 762
JOURNAL OF BIOCHEMICAL AND BIOPHYSICAL METHODS, vol. 64, no. 3, 2005, pages 207 - 215
DIABETES TECHNOLOGY & THERAPEUTICS, vol. 13, no. 7, 2011, pages 743 - 775
CAS , no. 186689-07-6
Attorney, Agent or Firm:
SINO-CREATIVITY INTELLECTUAL PROPERTY LAW FIRM (CN)
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