Title:
ARYL-INDANE COMPOUNDS FOR USE AS INHIBITORS OF P-GLYCOPROTEIN MEDIATED TRANSPORT
Document Type and Number:
WIPO Patent Application WO2002030915
Kind Code:
A3
Abstract:
A new family of compounds, particularly aryl-indane compounds, is disclosed. The compounds may be used as inhibitors of P-glycoprotein-mediated transport. Use of the compounds to enhance bioavailability and to modulate multi-drug resistance to chemotherapeutic agents is disclosed.
Inventors:
MELIKIAN-BADALIAN ANITA (US)
Application Number:
PCT/US2001/032017
Publication Date:
March 27, 2003
Filing Date:
October 11, 2001
Export Citation:
Assignee:
AVLAN LTD (GB)
MELIKIAN-BADALIAN ANITA (US)
MELIKIAN-BADALIAN ANITA (US)
International Classes:
A61P43/00; C07C62/34; C07C69/734; C07C69/757; C07C217/74; C07C233/78; C07C235/40; C07C235/50; C07C235/60; C07C275/24; C07C311/17; C07D295/096; C07D295/185; C07D295/205; C07F7/18; (IPC1-7): C07D295/18; A61K31/495; A61P43/00; C07C43/23; C07C62/34; C07C69/757; C07C217/58; C07C235/40; C07C247/10; C07C275/24; C07C309/65; C07C311/20; C07D295/20; C07D317/70
Foreign References:
| EP0757055A2 | 1997-02-05 |
Other References:
JATON, JEAN-CLAUDE ET AL: "The Secalosides, Novel Tumor Cell Growth Inhibitory Glycosides from a Pollen Extract", JOURNAL OF NATURAL PRODUCTS (1997), 60(4), 356-360, XP008005164
KUO, YUEH-HSIUNG ET AL: "Studies on acidic dimerization of 3,4-dioxygenated cinnamate or 1-phenylpropene to arylindane lignans", CHEM. PHARM. BULL. (1995), 43(8), 1267-71, XP002204054
LIN, MEI-TSU ET AL: "SAR analysis of the Epstein-Barr virus DNA polymerase inhibitors", CHINESE PHARMACEUTICAL JOURNAL (TAIPEI) (1998), 50(1), 13-24, XP008005167
KATO, TADAHIRO ET AL: "Isolation and synthesis of new antioxidants from sunflower seeds", NATURAL PRODUCT LETTERS (1997), 9(3), 161-165, XP008005163
AL-FARHAN, EMILE ET AL: "Dimerization of 3,4-disubstituted cinnamic acids and esters", SYNTHESIS (1992), (10), 959-61, XP002204055
FREUDENBERG ET AL.: "Die polymerisation des Coniferylalkohols durch Säure", CHEM. BER, vol. 97, 1964, pages 903 - 8, XP002204056
LUEDEMANN, HANS D. ET AL: "Carbon-13 NMR spectra of lignins. 1. Chemical shifts of monomeric and dimeric model substances", MAKROMOL. CHEM. (1974), 175(8), 2393-407, XP008005165
KUO, YUEH-HSIUNG ET AL: "Studies on acidic dimerization of 3,4-dioxygenated cinnamate or 1-phenylpropene to arylindane lignans", CHEM. PHARM. BULL. (1995), 43(8), 1267-71, XP002204054
LIN, MEI-TSU ET AL: "SAR analysis of the Epstein-Barr virus DNA polymerase inhibitors", CHINESE PHARMACEUTICAL JOURNAL (TAIPEI) (1998), 50(1), 13-24, XP008005167
KATO, TADAHIRO ET AL: "Isolation and synthesis of new antioxidants from sunflower seeds", NATURAL PRODUCT LETTERS (1997), 9(3), 161-165, XP008005163
AL-FARHAN, EMILE ET AL: "Dimerization of 3,4-disubstituted cinnamic acids and esters", SYNTHESIS (1992), (10), 959-61, XP002204055
FREUDENBERG ET AL.: "Die polymerisation des Coniferylalkohols durch Säure", CHEM. BER, vol. 97, 1964, pages 903 - 8, XP002204056
LUEDEMANN, HANS D. ET AL: "Carbon-13 NMR spectra of lignins. 1. Chemical shifts of monomeric and dimeric model substances", MAKROMOL. CHEM. (1974), 175(8), 2393-407, XP008005165
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