Title:
ARYL PROPIONIC ACID DERIVATIVE, PHARMACEUTICAL COMPOSITION, AND METHOD FOR PREPARATION THEREOF AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/052936
Kind Code:
A1
Abstract:
Provided are the aryl propionic acid derivative shown in formula (I), pharmaceutical composition, and method for preparation thereof and application thereof. The aryl propionic acid derivative described has good half-life, pharmacokinetic properties, and in vitro stability, can, when made into a formulation, achieve the functions of increasing effectiveness and reducing toxicity, and improves the defects of conventional non-steroidal anti-inflammatory drugs, such as frequent dosing, gastrointestinal side effects, and poor patient compliance.
Inventors:
YE HAI (CN)
MIN TAO (CN)
LV TIAN (CN)
ZHOU WENLIANG (CN)
XU YING (CN)
FENG YUNQING (CN)
MIN TAO (CN)
LV TIAN (CN)
ZHOU WENLIANG (CN)
XU YING (CN)
FENG YUNQING (CN)
Application Number:
PCT/CN2021/117108
Publication Date:
March 17, 2022
Filing Date:
September 08, 2021
Export Citation:
Assignee:
NANJING HERON PHARMACEUTICAL SCIENCE AND TECH CO LTD (CN)
International Classes:
C07C69/73; A61K31/216; A61K31/225; A61P29/00; C07C59/72; C07C59/90; C07C69/38
Domestic Patent References:
| WO2014065577A1 | 2014-05-01 |
Foreign References:
| CN111635309A | 2020-09-08 | |||
| CN1069484A | 1993-03-03 | |||
| CN111635315A | 2020-09-08 | |||
| CN106661061A | 2017-05-10 | |||
| US4407823A | 1983-10-04 | |||
| CN102333754A | 2012-01-25 | |||
| CN101506161A | 2009-08-12 |
Other References:
YAMAKAWA, NAOKI ET AL.: "Properties and Synthesis of 2-{2-Fluoro (or Bromo)-4-[(2- oxocyclopentyl)methyl]phenyl}propanoic Acid: Nonsteroidal Anti-inflammatory Drugs with Low Membrane Permeabilizing and Gastric Lesion-Producing Activitie s", JOURNAL OF MEDICINAL CHEMISTRY, vol. 53, no. 21, 18 October 2010 (2010-10-18), pages 7879 - 7882, XP055073416, DOI: 10.1021/jm101116s
Attorney, Agent or Firm:
BEYOND ATTORNEYS AT LAW (CN)
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