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Title:
ARYL SULFONAMIDES
Document Type and Number:
WIPO Patent Application WO2004046092
Kind Code:
A3
Abstract:
Compounds of formula (I) (in which the variables L, X, Y and Z are as defined in the claims) are provided that act as potent antagonists of the CCR9 receptor, and which have been further confirmed in animal testing for inflammation, one of the hallmark disease states for CCR9. The compounds are generally aryl sulphonamide derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR9-mediated diseases, and as controls in assays for the identification of CCR9 antagonists.

Inventors:
UGASHE SOLOMON
ZHENG WEI
WRIGHT J J
PENNELL ANDREW
Application Number:
PCT/US2003/036766
Publication Date:
July 15, 2004
Filing Date:
November 17, 2003
Export Citation:
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Assignee:
CHEMOCENTRYX (US)
International Classes:
A61P29/00; C07D213/26; C07D213/50; C07D213/70; C07D213/74; C07D213/84; C07D213/89; C07D241/12; C07D413/12; (IPC1-7): C07D413/12; C07D213/50; C07D213/89; C07D213/74; C07D213/70; C07D213/26; C07D241/12; C07D213/84; A61K31/44; A61P29/00
Domestic Patent References:
WO2002030358A22002-04-18
WO2003099773A12003-12-04
Foreign References:
Other References:
R. SILVESTRI, ET AL.: "Anti-HIV-1 NNRT agents: acylamino pyrryl aryl sulphones (APASs) as truncated analogues of tricyclic PBTDs", MEDICINAL CHEMISTRY RESEARCH, vol. 11, no. 4, 2002, BIRKHĂ„USER, BOSTON, US, pages 195 - 218, XP008030138, ISSN: 1054-2523
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