Title:
ASSAY ENHANCEMENT BY SELECTIVE DEPOSITION AND BINDING ON AMPLIFICATION STRUCTURES
Document Type and Number:
WIPO Patent Application WO/2014/197096
Kind Code:
A3
Abstract:
This disclosure provides, among other things, a method for enhancing detection of an analyte that is bound to a substrate comprising a signal amplification layer on a surface of the substrate, wherein the signal amplification layer comprises high-amplification regions and low-amplification regions, and the high-amplification regions amplify signals at said surface more than the low-amplification regions. The method comprises selectively masking the low-amplification regions of the substrate, thereby increasing the probability that an analyte will bind to a high-amplification region and be detected.
Inventors:
CHOU STEPHEN Y (US)
Application Number:
PCT/US2014/029979
Publication Date:
January 29, 2015
Filing Date:
March 15, 2014
Export Citation:
Assignee:
UNIV PRINCETON (US)
International Classes:
G01N21/27; G01N21/63
Domestic Patent References:
| WO2011105679A2 | 2011-09-01 |
Foreign References:
| US20110166045A1 | 2011-07-07 | |||
| US6093558A | 2000-07-25 | |||
| US20130115413A1 | 2013-05-09 | |||
| US20030203405A1 | 2003-10-30 |
Attorney, Agent or Firm:
KEDDIE, James S. (Field & Francis LLP1900 University Avenue, Suite 20, East Palo Alto California, US)
Download PDF: