Title:
ASYMMETRICALLY BRANCHED DEGRADABLE POLYETHYLENE GLYCOL DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/2021/060443
Kind Code:
A1
Abstract:
Provided is a high-molecular-weight branched, degradable polyethylene glycol derivative which does not cause cell vacuoles. The branched, degradable polyethylene glycol derivative represented by formula (1) includes an oligopeptide that decomposes intracellularly in each molecule. (In the formula, k1 and k2 are independently 1–12, j1 and j2 are independently 45–950, R is a hydrogen atom, a substituted or unsubstituted C1-12 alkyl group, a substituted aryl group, an aralkyl group, or a heteroalkyl group, Z is an oligopeptide which is degraded by intracellular enzymes, X is a functional group which can react with a biological substance, and L1 and L2 are independently single bonds or divalent spacers.)
Inventors:
HAMURA KEN (JP)
YOSHIOKA HIROKI (JP)
OSAKAMA KAZUKI (JP)
NISHIYAMA NOBUHIRO (JP)
YOSHIOKA HIROKI (JP)
OSAKAMA KAZUKI (JP)
NISHIYAMA NOBUHIRO (JP)
Application Number:
PCT/JP2020/036199
Publication Date:
April 01, 2021
Filing Date:
September 25, 2020
Export Citation:
Assignee:
NOF CORP (JP)
TOKYO INST TECH (JP)
TOKYO INST TECH (JP)
International Classes:
C08G65/333; A61K47/60; A61K47/64; C07K5/037; C07K5/068; C07K5/072; C07K5/09; C07K5/093; C08G81/00
Domestic Patent References:
| WO2005108463A2 | 2005-11-17 | |||
| WO2006088248A1 | 2006-08-24 |
Foreign References:
| JP2009527581A | 2009-07-30 | |||
| JP2014208786A | 2014-11-06 | |||
| JP2011079934A | 2011-04-21 | |||
| JP2019176251A | 2019-10-10 |
Other References:
DANIEL G. RUDMANN ET AL., TOXICOL. PATHOL., vol. 41, 2013, pages 970 - 983
FRANCESCO M VERONESE ET AL., BIOCONJUGATE CHEM., vol. 16, 2005, pages 775 - 784
JIYUAN YANG ET AL., MARCOMOL. BIOSCI., vol. 10, no. 4, 2010, pages 445 - 454
YULIA VUGMEYSTERANG ET AL., BIOCONJUGATE CHEM., vol. 23, 2012, pages 1452 - 1462
KYTE JDOOLITTLE RF, J MOL BIOL, vol. 157, 1982, pages 105 - 132
HARRIS, J. M.: "Poly (Ethylene Glycol) Chemistry", 1992, PLENUM PRESS
HERMANSON, G. T.: "Bioconjugate Techniques", 2008, ACADEMIC PRESS
"PEGylated Protein Drugs: Basic Science and Clinical Applications", 2009, BIRKHAUSER: BASEL
WUTS, P. G. M.GREENE, T. W.: "Protective Groups in Organic Synthesis", 2007, WILEY-INTERSCIENCE
See also references of EP 4036150A4
FRANCESCO M VERONESE ET AL., BIOCONJUGATE CHEM., vol. 16, 2005, pages 775 - 784
JIYUAN YANG ET AL., MARCOMOL. BIOSCI., vol. 10, no. 4, 2010, pages 445 - 454
YULIA VUGMEYSTERANG ET AL., BIOCONJUGATE CHEM., vol. 23, 2012, pages 1452 - 1462
KYTE JDOOLITTLE RF, J MOL BIOL, vol. 157, 1982, pages 105 - 132
HARRIS, J. M.: "Poly (Ethylene Glycol) Chemistry", 1992, PLENUM PRESS
HERMANSON, G. T.: "Bioconjugate Techniques", 2008, ACADEMIC PRESS
"PEGylated Protein Drugs: Basic Science and Clinical Applications", 2009, BIRKHAUSER: BASEL
WUTS, P. G. M.GREENE, T. W.: "Protective Groups in Organic Synthesis", 2007, WILEY-INTERSCIENCE
See also references of EP 4036150A4
Attorney, Agent or Firm:
TAKASHIMA, Hajime (JP)
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