Title:
AURANOFIN AND AURANOFIN ANALOGS USEFUL TO TREAT PROLIFERATIVE DISEASE AND DISORDERS
Document Type and Number:
WIPO Patent Application WO/2012/142615
Kind Code:
A3
Abstract:
Auranofin analogs and pharmaceutical compositions which inhibit p-STAT3 are provided together methods of synthesizing and methods of using the compounds. Also provided are methods of treating p-STAT3 diseases and disorders in a patient in need thereof by administering a therapeutically effective amount of one or more of these compounds, alone or in combination with another drug therapy. The compounds and pharmaceutical compositions disclosed are useful to treat proliferative diseases and disorders including, but not limited to, cancer.
Inventors:
PRIEBE WALDEMAR (US)
KATO TAKAYUKI (US)
FOKT IZABELA (US)
CONRAD CHARLES (US)
MADDEN TIMOTHY (US)
SKORA STANISLAW (US)
KATO TAKAYUKI (US)
FOKT IZABELA (US)
CONRAD CHARLES (US)
MADDEN TIMOTHY (US)
SKORA STANISLAW (US)
Application Number:
PCT/US2012/033837
Publication Date:
January 31, 2013
Filing Date:
April 16, 2012
Export Citation:
Assignee:
UNIV TEXAS (US)
PRIEBE WALDEMAR (US)
KATO TAKAYUKI (US)
FOKT IZABELA (US)
CONRAD CHARLES (US)
MADDEN TIMOTHY (US)
SKORA STANISLAW (US)
PRIEBE WALDEMAR (US)
KATO TAKAYUKI (US)
FOKT IZABELA (US)
CONRAD CHARLES (US)
MADDEN TIMOTHY (US)
SKORA STANISLAW (US)
International Classes:
C07H15/14; A61K31/70; A61P35/00; C07H3/04
Domestic Patent References:
| WO2010005799A2 | 2010-01-14 | |||
| WO2003018598A2 | 2003-03-06 |
Foreign References:
| US20050043250A1 | 2005-02-24 | |||
| US20100130434A1 | 2010-05-27 | |||
| US20050143336A1 | 2005-06-30 | |||
| US20110003758A1 | 2011-01-06 |
Other References:
KIM, N. H. ET AL.: "Auranofin blocks interleukin-6 signalling by inhibiting p hosphorylation of JAK1 and STAT3.", IMMUNOLOGY., vol. 122, no. 4, 2007, pages 6 07 - 614, XP055237295, DOI: doi:10.1111/j.1365-2567.2007.02679.x
Attorney, Agent or Firm:
PARKER, David, L. (PLLC1120 S. Capital of Texas Highway,Building One, Suite 20, Austin TX, US)
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