Title:
AVERMECTIN DERIVATIVES
Document Type and Number:
WIPO Patent Application WO/2000/047597
Kind Code:
A1
Abstract:
Avermectin derivatives represented by general formula (I) or salts thereof: wherein -X---Y- is -CH=CH-, -CH¿2?-C(=O)-, -CH¿2?-CH¿2?-, or -CH¿2?-CH(R?13¿)-, for example, (1) when -X---Y- is -CH=CH-, R?1¿ is (R?11¿) (R?12¿)C [wherein R?11¿ is optionally substituted lower alkyl, formyl, lower alkoxycarbonyl, or the like, and R?12¿ is hydrogen or lower alkyl], and R?2¿ is hydroxyl, tri (lower alkyl) silyloxy, or the like and linked by a single bond to the 5-position carbon atom, or R?2¿ and the 5-position carbon atom may be united to form a carbonyl or hydroxime group, and (2) when -X---Y- is -CH¿2?-C(=O)-, R?1¿ is (R?11a¿) (R?12a¿)C [wherein R?11a¿ is lower alkoxycarbonyl or -COOCH¿2?CH=CH¿2?, and R?12a¿ is hydrogen], and R?2¿ is hydroxyl or tri (lower alkyl) silyloxy.
Inventors:
OMURA SATOSHI (JP)
SUNAZUKA TOSHIAKI (JP)
TURBERG ANDREAS (DE)
SAMSON-HIMMELSTJERNA GEORG VON (DE)
HANSEN OLAF (DE)
HARDER ACHIM (DE)
SUNAZUKA TOSHIAKI (JP)
TURBERG ANDREAS (DE)
SAMSON-HIMMELSTJERNA GEORG VON (DE)
HANSEN OLAF (DE)
HARDER ACHIM (DE)
Application Number:
PCT/JP2000/000691
Publication Date:
August 17, 2000
Filing Date:
February 09, 2000
Export Citation:
Assignee:
KITASATO INST (JP)
OMURA SATOSHI (JP)
SUNAZUKA TOSHIAKI (JP)
TURBERG ANDREAS (DE)
SAMSON HIMMELSTJERNA GEORG VON (DE)
HANSEN OLAF (DE)
HARDER ACHIM (DE)
OMURA SATOSHI (JP)
SUNAZUKA TOSHIAKI (JP)
TURBERG ANDREAS (DE)
SAMSON HIMMELSTJERNA GEORG VON (DE)
HANSEN OLAF (DE)
HARDER ACHIM (DE)
International Classes:
A01N43/02; A01N43/04; A61K31/7048; A61P33/00; C07D305/00; C07H17/08; (IPC1-7): C07H17/08; A61K31/7048; A61P33/00
Domestic Patent References:
| WO1994029328A1 | 1994-12-22 |
Foreign References:
| EP0401029A1 | 1990-12-05 | |||
| EP0351923A2 | 1990-01-24 |
Other References:
See also references of EP 1160252A4
Attorney, Agent or Firm:
Imamura, Masazumi (KRF Building 5-5 Kyobashi 1-chome Chuo-ku, Tokyo, JP)
Download PDF: