Title:
AVERMECTIN DERIVATIVES
Document Type and Number:
WIPO Patent Application WO/2002/012248
Kind Code:
A1
Abstract:
Compounds represented by the general formula (I) or salts thereof wherein -X---Y- is -CH=CH-, -CH¿2?-CH¿2?-, or the like; the symbol ---- between R?1¿ and the 4'-position carbon atom represents a single bond or a double bond; and the symbol ---- between R?2¿ and the 5-position carbon atom represents a single bond or a double bond, for example, (1) when -X---Y- is -CH=CH- or -CH¿2?-CH¿2?- and the symbol ---- between R?1¿ and the 4'-position carbon atom represents a double bond, R?1¿ is =C(R?11¿)(R?12¿) (wherein R?11¿ is lower alkyl or the like, and R?12¿ is hydrogen or the like) or the like, and R?2¿ is hydroxyl or the like, or R?2¿ together with the 5-position carbon atom represents carbonyl, or (2) when -X---Y- is -CH=CH- or -CH¿2?-CH¿2?- and the symbol ---- between R?1¿ and the 4'-position carbon atom represents a single bond, R?1¿ is -OCH(R?1a¿)(R?1b¿) (wherein R?1a¿ is lower alkyl or the like, and R?1b¿ is hydrogen or the like) or the like, and R?2¿ is hydroxyl or the like.
Inventors:
OMURA SATOSHI (JP)
NAGAI KENICHIRO (JP)
SUNAZUKA TOSHIAKI (JP)
NAGAI KENICHIRO (JP)
SUNAZUKA TOSHIAKI (JP)
Application Number:
PCT/JP2001/006803
Publication Date:
February 14, 2002
Filing Date:
August 08, 2001
Export Citation:
Assignee:
KITASATO INST (JP)
OMURA SATOSHI (JP)
NAGAI KENICHIRO (JP)
SUNAZUKA TOSHIAKI (JP)
OMURA SATOSHI (JP)
NAGAI KENICHIRO (JP)
SUNAZUKA TOSHIAKI (JP)
International Classes:
A61K31/365; A61P33/10; C07H17/08; (IPC1-7): C07D493/22; A61K31/35; A61P33/10
Domestic Patent References:
| WO1993018778A1 | 1993-09-30 | |||
| WO1994029328A1 | 1994-12-22 | |||
| WO1995022552A1 | 1995-08-24 |
Foreign References:
| EP0351923A2 | 1990-01-24 | |||
| EP0008184A1 | 1980-02-20 | |||
| EP0480693A2 | 1992-04-15 |
Attorney, Agent or Firm:
Imamura, Masazumi (Kyobashi-Nisshoku Bldg. 8-7, Kyobashi 1-chom, Chuo-ku Tokyo, JP)
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