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Patent Searching and Data


Title:
AVERMECTIN DERIVATIVES
Document Type and Number:
WIPO Patent Application WO/2002/012261
Kind Code:
A1
Abstract:
Compounds of the general formula (I) or salts thereof, exhibiting antiparasitic activities wherein -X---Y- is -CH=CH- or the like; the symbol ---- between R?2¿ and the 5-position carbon atom is a single bond or a double bond; R?1¿ is lower alkyl, formyl, carboxyl, lower alkoxycarbonyl (the lower alkyl moiety of which may be substituted with a heterocyclic group), or the like; R?1a¿ is hydrogen, with the proviso that when R?1¿ is lower alkoxycarbonyl or the like, R?1a¿ may be lower alkoxycarbonyl or the like; when the symbol ---- between R?2¿ and the 5-position carbon atom is a single bond, R?2¿ is hydroxyl or the like, while when it is a double bond, R?2¿ and the 5-position carbon atom unite to form a hydroxime group {-C(=NOH)} or the like; and R?3¿ is hydroxyl or tri(lower alkyl)silyloxy.

Inventors:
OMURA SATOSHI (JP)
NAGAI KENICHIRO (JP)
SUNAZUKA TOSHIAKI (JP)
Application Number:
PCT/JP2001/006802
Publication Date:
February 14, 2002
Filing Date:
August 08, 2001
Export Citation:
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Assignee:
KITASATO INST (JP)
OMURA SATOSHI (JP)
NAGAI KENICHIRO (JP)
SUNAZUKA TOSHIAKI (JP)
International Classes:
A61P33/10; C07H17/08; C07H19/01; (IPC1-7): C07H17/08; A61K31/7048; A61P33/10
Domestic Patent References:
WO1995022552A11995-08-24
WO1995004746A11995-02-16
Foreign References:
EP0506331A11992-09-30
EP0456509A11991-11-13
Attorney, Agent or Firm:
Imamura, Masazumi (Kyobashi-Nisshoku Bldg. 8-, Kyobashi 1-chome Chuo-ku Tokyo, JP)
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