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Title:
AVIAN EGG DROP SYNDROME VIRUS TFIBER PROTEIN FRAGMENT, VACCINE COMPOSITION PREPARED THEREFROM, PREPARATION METHOD, AND APPLICATION
Document Type and Number:
WIPO Patent Application WO/2021/073178
Kind Code:
A1
Abstract:
Provided are an avian egg drop syndrome virus tFiber protein fragment encoded by a nucleotide sequence represented by SEQ ID NO. 2 or a degenerate sequence thereof, and a vaccine composition prepared from the protein fragment. The fragment has good immunogenicity and can be used with a variety of antigens to prepare a combined vaccine, and complete protection can be achieved for chickens and ducks.

Inventors:
TIAN KEGONG (CN)
WANG MENGYUE (CN)
LIU WUJIE (CN)
ZHANG XUKE (CN)
Application Number:
PCT/CN2020/101961
Publication Date:
April 22, 2021
Filing Date:
July 14, 2020
Export Citation:
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Assignee:
PULIKE BIOLOGICAL ENG INC (CN)
International Classes:
A61K39/235; A61P31/20; C07K14/075
Domestic Patent References:
WO2004078977A12004-09-16
WO2015024932A12015-02-26
Foreign References:
CN108653724A2018-10-16
CN108653725A2018-10-16
Other References:
SONG YAPENG; WEI QIANG; LIU YUNCHAO; BAI YILIN; DENG RUIGUANG; XING GUANGXU; ZHANG GAIPING: "Development of novel subunit vaccine based on truncated fiber protein of egg drop syndrome virus and its immunogenicity in chickens", VIRUS RESEARCH, AMSTERDAM, NL, vol. 272, 20 August 2019 (2019-08-20), NL, XP085805455, ISSN: 0168-1702, DOI: 10.1016/j.virusres.2019.197728
HARAKUNI TETSUYA; ANDOH KIYOHIKO; SAKAMOTO RYU-ICHI; TAMAKI YUKIHIRO; MIYATA TAKESHI; UEFUJI HIROTAKA; YAMAZAKI KEN-ICHI; ARAKAWA : "Fiber knob domain lacking the shaft sequence but fused to a coiled coil is a candidate subunit vaccine against egg-drop syndrome", VACCINE, ELSEVIER, AMSTERDAM, NL, vol. 34, no. 27, 20 April 2016 (2016-04-20), AMSTERDAM, NL, pages 3184 - 3190, XP029569612, ISSN: 0264-410X, DOI: 10.1016/j.vaccine.2016.04.005
Attorney, Agent or Firm:
CHINA ZHENGHE INTELLECTUAL PROPERTY AGENCY (CN)
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