Title:
AZA-ERGOLINE DERIVATIVE AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/161493
Kind Code:
A1
Abstract:
An aza-ergoline derivative and a preparation method therefor and an application thereof. The derivative has a structure as shown in formula (I). The aza-ergoline derivative has good affinity, agonistic activity or selectivity to a dopamine D2 receptor.
Inventors:
CHENG JIANJUN (CN)
WANG SHENG (CN)
WANG HUAN (CN)
FAN LUYU (CN)
CHEN ZHANGCHENG (CN)
YU JING (CN)
QI JIANZHONG (CN)
NIE FEN (CN)
WANG SHENG (CN)
WANG HUAN (CN)
FAN LUYU (CN)
CHEN ZHANGCHENG (CN)
YU JING (CN)
QI JIANZHONG (CN)
NIE FEN (CN)
Application Number:
PCT/CN2022/075094
Publication Date:
August 04, 2022
Filing Date:
January 29, 2022
Export Citation:
Assignee:
UNIV SHANGHAI TECH (CN)
CENTER FOR EXCELLENCE IN MOLECULAR CELL SCIENCE CHINESE ACAD OF SCIENCES (CN)
CENTER FOR EXCELLENCE IN MOLECULAR CELL SCIENCE CHINESE ACAD OF SCIENCES (CN)
International Classes:
A61K31/4375; C07D471/16; A61P25/00
Domestic Patent References:
| WO2011088838A1 | 2011-07-28 | |||
| WO2011088836A1 | 2011-07-28 | |||
| WO2011088836A1 | 2011-07-28 | |||
| WO2011088838A1 | 2011-07-28 |
Other References:
KROGSGAARD-LARSEN NIELS, JENSEN ANDERS A., SCHRØDER TENNA J., CHRISTOFFERSEN CLAUS. T., KEHLER JAN: "Novel Aza-analogous Ergoline Derived Scaffolds as Potent Serotonin 5-HT 6 and Dopamine D 2 Receptor Ligands.", JOURNAL OF MEDICINAL CHEMISTRY, vol. 57, no. 13, 10 July 2014 (2014-07-10), US , pages 5823 - 5828, XP055954880, ISSN: 0022-2623, DOI: 10.1021/jm5003759
KROGSGAARD-LARSEN, N. ; BEGTRUP, M. ; FRYDENVANG, K. ; KEHLER, J.: "Syntheses of aza-analogous iso-ergoline scaffolds using carbene mediated C-H insertion", TETRAHEDRON, vol. 66, no. 47, 20 November 2010 (2010-11-20), AMSTERDAM, NL , pages 9297 - 9303, XP027443744, ISSN: 0040-4020
FRANKELSCHWARTZ, THE ADV PSYCHOPHARMACOL, vol. 7, no. 1, 2017, pages 29 - 41
SAHLITARAZI, EXPERT OPIN DRUG DISCOV, vol. 13, no. 1, 2018, pages 103 - 110
BLAIR, DRUGS, vol. 80, no. 4, 2020, pages 417 - 423
FANTAN ET AL., NAT COMM, vol. 11, 2020, pages 1074
KROGSGAARD-LARSEN ET AL., J. MED. CHEM., vol. 57, 2014, pages 5823 - 5828
KROGSGAARD-LARSEN ET AL., J. MED. CHEM, vol. 57, 2014, pages 5823 - 5828
KROGSGAARD-LARSEN, N. ; BEGTRUP, M. ; FRYDENVANG, K. ; KEHLER, J.: "Syntheses of aza-analogous iso-ergoline scaffolds using carbene mediated C-H insertion", TETRAHEDRON, vol. 66, no. 47, 20 November 2010 (2010-11-20), AMSTERDAM, NL , pages 9297 - 9303, XP027443744, ISSN: 0040-4020
FRANKELSCHWARTZ, THE ADV PSYCHOPHARMACOL, vol. 7, no. 1, 2017, pages 29 - 41
SAHLITARAZI, EXPERT OPIN DRUG DISCOV, vol. 13, no. 1, 2018, pages 103 - 110
BLAIR, DRUGS, vol. 80, no. 4, 2020, pages 417 - 423
FANTAN ET AL., NAT COMM, vol. 11, 2020, pages 1074
KROGSGAARD-LARSEN ET AL., J. MED. CHEM., vol. 57, 2014, pages 5823 - 5828
KROGSGAARD-LARSEN ET AL., J. MED. CHEM, vol. 57, 2014, pages 5823 - 5828
Attorney, Agent or Firm:
SHANGHAI BESHINING LAW OFFICE (CN)
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