Title:
AZA-RING DERIVATIVES AND THEIR USE AS MONOAMINE NEUROTRANSMITTER RE-UPTAKE INHIBITORS
Document Type and Number:
WIPO Patent Application WO2004113297
Kind Code:
A3
Abstract:
This invention relates to novel aza-ring derivatives useful as monoamine neurotransmitter re-uptake inhibitors. In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.
Inventors:
PETERS DAN (DK)
OLSEN GUNNAR M (DK)
NIELSEN ELSEBET OESTERGAARD (DK)
SCHEEL-KRUEGER JOERGEN (DK)
OLSEN GUNNAR M (DK)
NIELSEN ELSEBET OESTERGAARD (DK)
SCHEEL-KRUEGER JOERGEN (DK)
Application Number:
PCT/EP2004/051166
Publication Date:
January 19, 2006
Filing Date:
June 18, 2004
Export Citation:
Assignee:
NEUROSEARCH AS (DK)
PETERS DAN (DK)
OLSEN GUNNAR M (DK)
NIELSEN ELSEBET OESTERGAARD (DK)
SCHEEL-KRUEGER JOERGEN (DK)
PETERS DAN (DK)
OLSEN GUNNAR M (DK)
NIELSEN ELSEBET OESTERGAARD (DK)
SCHEEL-KRUEGER JOERGEN (DK)
International Classes:
C07D205/04; C07D207/12; C07D211/46; C07D211/54; C07D223/08; C07D401/12; C07D409/12
Domestic Patent References:
| WO2001034598A1 | 2001-05-17 | |||
| WO2000010997A1 | 2000-03-02 | |||
| WO1999043647A1 | 1999-09-02 | |||
| WO1999024422A1 | 1999-05-20 | |||
| WO2003077907A1 | 2003-09-25 | |||
| WO2001087276A1 | 2001-11-22 | |||
| WO2003062224A1 | 2003-07-31 | |||
| WO2001046146A1 | 2001-06-28 | |||
| WO2003018556A1 | 2003-03-06 |
Foreign References:
| GB2085427A | 1982-04-28 | |||
| US3577432A | 1971-05-04 | |||
| US6281243B1 | 2001-08-28 | |||
| EP0863136A1 | 1998-09-09 | |||
| US5130309A | 1992-07-14 | |||
| US5852037A | 1998-12-22 | |||
| US5763457A | 1998-06-09 | |||
| EP0709381A1 | 1996-05-01 | |||
| JPH0314566A | 1991-01-23 | |||
| US5789402A | 1998-08-04 | |||
| EP0232937A2 | 1987-08-19 | |||
| US4735952A | 1988-04-05 |
Other References:
LEE, JUNG ET AL: "Synthesis and structure-activity relationship of novel pyridyl ethers for the nicotinic acetylcholine receptor", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS , 10(10), 1063-1066 CODEN: BMCLE8; ISSN: 0960-894X, 2000, XP004204606
ADACHI, MAKOTO ET AL: "Aminohaloborane in organic synthesis. IX. Exclusive ortho acylation reaction of N- monoaminoalkylanilines", CHEMICAL & PHARMACEUTICAL BULLETIN , 33(5), 1826-35 CODEN: CPBTAL; ISSN: 0009-2363, 1985, XP002087531
HILLEGAART, VIVEKA ET AL: "Facilitation and inhibition of male rat ejaculatory behavior by the respective 5-HT1A and 5-HT1B receptor agonists 8-OH-DPAT and anpirtoline, as evidenced by use of the corresponding new and selective receptor antagonists NAD-299 and NAS-181", BRITISH JOURNAL OF PHARMACOLOGY , 125(8), 1733-1743 CODEN: BJPCBM; ISSN: 0007-1188, 1998, XP009054921
FORBES, IAN T. ET AL: "SB-656104-A: A novel 5-HT7 receptor antagonist with improved in vivo properties", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS , 12(22), 3341-3344 CODEN: BMCLE8; ISSN: 0960-894X, 2002, XP009055051
MENSONIDES-HARSEMA, MARGUERITE M. ET AL: "Synthesis and in Vitro and in Vivo Functional Studies of Ortho-Substituted Phenylpiperazine and N-Substituted 4-N-(o-Methoxyphenyl)aminopiperidine Analogs of WAY100635", JOURNAL OF MEDICINAL CHEMISTRY , 43(3), 432-439 CODEN: JMCMAR; ISSN: 0022-2623, 2000, XP009055050
RADL, STANISLAV ET AL: "Synthesis and analgesic activity of some quinazoline analogs of anpirtoline", ARCHIV DER PHARMAZIE (WEINHEIM, GERMANY) , 333(11), 381-386 CODEN: ARPMAS; ISSN: 0365-6233, 2000, XP009055116
RADL, STANISLAV ET AL: "Synthesis and analgesic activity of some condensed analogs of anpirtoline", ARCHIV DER PHARMAZIE (WEINHEIM, GERMANY) , 332(6), 208-212 CODEN: ARPMAS; ISSN: 0365-6233, 1999, XP000996160
ADACHI, MAKOTO ET AL: "Aminohaloborane in organic synthesis. IX. Exclusive ortho acylation reaction of N- monoaminoalkylanilines", CHEMICAL & PHARMACEUTICAL BULLETIN , 33(5), 1826-35 CODEN: CPBTAL; ISSN: 0009-2363, 1985, XP002087531
HILLEGAART, VIVEKA ET AL: "Facilitation and inhibition of male rat ejaculatory behavior by the respective 5-HT1A and 5-HT1B receptor agonists 8-OH-DPAT and anpirtoline, as evidenced by use of the corresponding new and selective receptor antagonists NAD-299 and NAS-181", BRITISH JOURNAL OF PHARMACOLOGY , 125(8), 1733-1743 CODEN: BJPCBM; ISSN: 0007-1188, 1998, XP009054921
FORBES, IAN T. ET AL: "SB-656104-A: A novel 5-HT7 receptor antagonist with improved in vivo properties", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS , 12(22), 3341-3344 CODEN: BMCLE8; ISSN: 0960-894X, 2002, XP009055051
MENSONIDES-HARSEMA, MARGUERITE M. ET AL: "Synthesis and in Vitro and in Vivo Functional Studies of Ortho-Substituted Phenylpiperazine and N-Substituted 4-N-(o-Methoxyphenyl)aminopiperidine Analogs of WAY100635", JOURNAL OF MEDICINAL CHEMISTRY , 43(3), 432-439 CODEN: JMCMAR; ISSN: 0022-2623, 2000, XP009055050
RADL, STANISLAV ET AL: "Synthesis and analgesic activity of some quinazoline analogs of anpirtoline", ARCHIV DER PHARMAZIE (WEINHEIM, GERMANY) , 333(11), 381-386 CODEN: ARPMAS; ISSN: 0365-6233, 2000, XP009055116
RADL, STANISLAV ET AL: "Synthesis and analgesic activity of some condensed analogs of anpirtoline", ARCHIV DER PHARMAZIE (WEINHEIM, GERMANY) , 332(6), 208-212 CODEN: ARPMAS; ISSN: 0365-6233, 1999, XP000996160
Download PDF: