Title:
AZAHETEROARYL COMPOUND AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2021/032004
Kind Code:
A1
Abstract:
Disclosed in the present invention are an azaheteroaryl compound, a pharmaceutically acceptable salt thereof, and a solvate thereof. The present invention also provides a method for preparing said compound, a composition containing said compound, and a use of said compound in the preparation of a drug for treating a disease or disorder related to the mechanism of action of an EED protein and/or a PRC2 protein complex. (Formula 1)
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Inventors:
MA SHICHAO (CN)
ZHANG ZHONGGUO (CN)
ZHANG SONG (CN)
YUAN WENJIA (CN)
ZHANG ZHONGGUO (CN)
ZHANG SONG (CN)
YUAN WENJIA (CN)
Application Number:
PCT/CN2020/109232
Publication Date:
February 25, 2021
Filing Date:
August 14, 2020
Export Citation:
Assignee:
SHANGHAI BLUERAY BIOPHARMA CO LTD (CN)
International Classes:
A61K31/519; C07D519/00; A61P35/00; A61P35/02; C07D239/30; C07D307/93; C07D487/04
Domestic Patent References:
| WO2020156479A1 | 2020-08-06 | |||
| WO2019158025A1 | 2019-08-22 | |||
| WO2019158019A1 | 2019-08-22 | |||
| WO2019062435A1 | 2019-04-04 | |||
| WO2019152419A1 | 2019-08-08 | |||
| WO2017219948A1 | 2017-12-28 |
Foreign References:
| CN110734436A | 2020-01-31 | |||
| CN110563722A | 2019-12-13 | |||
| CN102869666A | 2013-01-09 | |||
| CN107108637A | 2017-08-29 | |||
| CN201910773333A | 2019-08-22 | |||
| US20160176882A1 | 2016-06-23 |
Other References:
J. CHESTERFIELD , J F W MCOMIE , E R SAYER: "Pyrimidines. Part VIII. Halogeno- and Hydrazino-pyrimidines", JOURNAL OF THE CHEMICAL SOCIETY, 1 January 1955 (1955-01-01), pages 3478 - 3481, XP055353639, ISSN: 0368-1769
DATABASE Registry 4 August 2011 (2011-08-04), ANONYMOUS: "RN 1314936-62-3", XP055783573, retrieved from STN Database accession no. 1314936-62-3
DATABASE REGISTRY 23 January 2013 (2013-01-23), ANONYMOUS: "- /1 -(C) FILE REGISTRY RN -1417360-98-5 REGISTRY ED -Entered STN: 23 Jan 2013 CN -1,2,4-Triazolo[4,3-c]pyrimidine, 5-chloro-8-fluoro- (CA INDEX NAME", XP055914641, retrieved from STN Database accession no. 1417360-98-5
DATABASE REGISTRY 13 July 2016 (2016-07-13), ANONYMOUS: "/1 -(C) FILE REGISTRY RN -1951411-29-2 REGISTRY ED -Entered STN: 13 Jul 2016 CN -1,2,4-Triazolo[4,3-c]pyrimidin-5-amine, 8-fluoro-N-[(5-fluoro-2,3-dihydro-4-benzofuranyl)methyl]- (CA INDEX NAME) ", XP055914642, retrieved from STN Database accession no. 1951411-29-2
CAREYSUNDBERG: "ADVANCED ORGANIC CHEMISTRY", vol. A, 2000, PLENUM PRESS
"Chiral Separations, Methods and Protocols, Methods in Molecular Biology", vol. 243, 2004
A.M. STALCUP, CHIRAL SEPARATIONS, ANNU. REV. ANAL. CHEM., vol. 3, 2010, pages 341 - 63
"Vogel's Encyclopedia of Practical Organic Chemistry", 1991, LONGMAN SCIENTIFIC AND TECHNICAL LTD., pages: 809 - 816
HELLER, ACC. CHEM. RES., vol. 23, 1990, pages 128
GREENE, T. W.P. G. M. WUTS: "The Pharmacological Basis of Therapeutics", 1999, MACK PUBLISHING CO.
DATABASE Registry 4 August 2011 (2011-08-04), ANONYMOUS: "RN 1314936-62-3", XP055783573, retrieved from STN Database accession no. 1314936-62-3
DATABASE REGISTRY 23 January 2013 (2013-01-23), ANONYMOUS: "- /1 -(C) FILE REGISTRY RN -1417360-98-5 REGISTRY ED -Entered STN: 23 Jan 2013 CN -1,2,4-Triazolo[4,3-c]pyrimidine, 5-chloro-8-fluoro- (CA INDEX NAME", XP055914641, retrieved from STN Database accession no. 1417360-98-5
DATABASE REGISTRY 13 July 2016 (2016-07-13), ANONYMOUS: "/1 -(C) FILE REGISTRY RN -1951411-29-2 REGISTRY ED -Entered STN: 13 Jul 2016 CN -1,2,4-Triazolo[4,3-c]pyrimidin-5-amine, 8-fluoro-N-[(5-fluoro-2,3-dihydro-4-benzofuranyl)methyl]- (CA INDEX NAME) ", XP055914642, retrieved from STN Database accession no. 1951411-29-2
CAREYSUNDBERG: "ADVANCED ORGANIC CHEMISTRY", vol. A, 2000, PLENUM PRESS
"Chiral Separations, Methods and Protocols, Methods in Molecular Biology", vol. 243, 2004
A.M. STALCUP, CHIRAL SEPARATIONS, ANNU. REV. ANAL. CHEM., vol. 3, 2010, pages 341 - 63
"Vogel's Encyclopedia of Practical Organic Chemistry", 1991, LONGMAN SCIENTIFIC AND TECHNICAL LTD., pages: 809 - 816
HELLER, ACC. CHEM. RES., vol. 23, 1990, pages 128
GREENE, T. W.P. G. M. WUTS: "The Pharmacological Basis of Therapeutics", 1999, MACK PUBLISHING CO.
Attorney, Agent or Firm:
SHANGHAI BESHINING LAW OFFICE (CN)
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