Title:
AZEPAN DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/2021/065898
Kind Code:
A1
Abstract:
Provided are: an azepan derivative represented by general formula (I) and a pharmaceutically acceptable salt thereof (in the formula: R1 represents a hydrogen atom, a C1-6 alkyl group which may have a substituent, etc.; R2 and R3 are the same as or different from each other, and represent a hydrogen atom, a C1-6 alkyl group which may have a substituent, etc.; R4 and R5 are the same as or different from each other, and represent a hydrogen atom, a C1-6 alkyl group which may have a substituent, etc.; R6 represents a hydrogen atom, a C1-6 alkyl group which may have a substituent, etc.; R7 and R8 are the same as or different from each other, and represent a hydrogen atom, a C1-6 alkyl group which may have a substituent, etc.; R9 and R10 are the same as or different from each other, and represent a hydrogen atom, a C1-6 alkyl group which may have a substituent, etc.; R11 represents a hydrogen atom, a C1-6 alkyl group which may have a substituent, etc.; A and B differently represent a methyl group, a carbonyl group, etc.; and X represents a nitrogen atom or an N-oxide.).
Inventors:
WATANABE YOSHIKAZU (JP)
SAITO DAISUKE (JP)
HAYASHIDA KOHEI (JP)
YAMAMOTO KOHEI (JP)
NAMIKI MAYU (JP)
SAITO DAISUKE (JP)
HAYASHIDA KOHEI (JP)
YAMAMOTO KOHEI (JP)
NAMIKI MAYU (JP)
Application Number:
PCT/JP2020/036868
Publication Date:
April 08, 2021
Filing Date:
September 29, 2020
Export Citation:
Assignee:
NIPPON CHEMIPHAR CO (JP)
International Classes:
A61P25/04; A61K31/55; A61K31/695; A61P17/04; A61P43/00; C07D471/08; C07D519/00; C07F7/10
Domestic Patent References:
| WO2020085234A1 | 2020-04-30 | |||
| WO2008143263A1 | 2008-11-27 | |||
| WO2010105179A2 | 2010-09-16 | |||
| WO2017223239A1 | 2017-12-28 | |||
| WO2010021149A1 | 2010-02-25 | |||
| WO1999005095A1 | 1999-02-04 | |||
| WO2011045383A2 | 2011-04-21 | |||
| WO2018148576A1 | 2018-08-16 | |||
| WO2016040515A1 | 2016-03-17 | |||
| WO2018160878A1 | 2018-09-07 |
Foreign References:
| JP2015500245A | 2015-01-05 | |||
| JP2010511717A | 2010-04-15 | |||
| JP2019179727A | 2019-10-17 | |||
| JP2008179554A | 2008-08-07 | |||
| JP2525552B2 | 1996-08-21 | |||
| US0963460A | 1910-07-05 |
Other References:
SUZUKI, SHINYA ET AL.: "Discovery of highly selective kappa-opioid receptor agnists: 10 alpha-hydroxy TRK-820 derivatives", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 27, 2017, pages 3920 - 3924, XP055710940
ISHIKAWA, KYOKO ET AL.: "C-homomorphinan derivatives as lead compounds to obtain safer and more clinically useful analgesics", CHEM. PHARM. BULL., vol. 65, 2017, pages 920 - 929, XP055815434
"Symposium Program and Abstract of 36th Annual Meeting of Japanese Narcotics Research Conference", JAPANESE NARCOTICS RESEARCH CONFERENCE, 2016, pages 37
TETRAHEDRON LETT., vol. 51, 2010, pages 2359
JOURNAL OF MEDICINAL CHEMISTRY, vol. 58, 2015, pages 5842
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 134, 2012, pages 11408
JOURNAL OF MEDICINAL CHEMISTRY, vol. 61, 2018, pages 8797
JOURNAL OF MEDICINAL CHEMISTRY, vol. 39, 1996, pages 2615
TETRAHEDRON LETTERS, vol. 48, 2007, pages 7413
ORGANIC LETTERS, vol. 11, 2009, pages 539
See also references of EP 4039331A4
ISHIKAWA, KYOKO ET AL.: "C-homomorphinan derivatives as lead compounds to obtain safer and more clinically useful analgesics", CHEM. PHARM. BULL., vol. 65, 2017, pages 920 - 929, XP055815434
"Symposium Program and Abstract of 36th Annual Meeting of Japanese Narcotics Research Conference", JAPANESE NARCOTICS RESEARCH CONFERENCE, 2016, pages 37
TETRAHEDRON LETT., vol. 51, 2010, pages 2359
JOURNAL OF MEDICINAL CHEMISTRY, vol. 58, 2015, pages 5842
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 134, 2012, pages 11408
JOURNAL OF MEDICINAL CHEMISTRY, vol. 61, 2018, pages 8797
JOURNAL OF MEDICINAL CHEMISTRY, vol. 39, 1996, pages 2615
TETRAHEDRON LETTERS, vol. 48, 2007, pages 7413
ORGANIC LETTERS, vol. 11, 2009, pages 539
See also references of EP 4039331A4
Attorney, Agent or Firm:
TANAI Sumio et al. (JP)
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