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Title:
B CELL VACCINE AGAINST EBV VIRUS ANTIGEN AND PREPARATION METHOD THEREFOR
Document Type and Number:
WIPO Patent Application WO/2021/027057
Kind Code:
A1
Abstract:
Provided are a B cell vaccine against a plurality of human susceptible viruses and a preparation method therefor. The B cell vaccine has anti-tumor and/or anti-virus preventive and/or therapeutic effects. Provided is a B cell composition, comprising B cells and viral antigens, the B cell composition being subjected to a certain dose of ionizing radiation irradiation treatment. Also provided is a B cell vaccine, comprising the B cell composition. Further provided are a preparation method for the B cell vaccine and a system for improving the presentation of B cell antigen.

Inventors:
YANG HANSHUO (CN)
WEI YUQUAN (CN)
Application Number:
PCT/CN2019/111889
Publication Date:
February 18, 2021
Filing Date:
October 18, 2019
Export Citation:
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Assignee:
CHENGDU IMMUNOHEALTH TECH COMPANY LIMITED (CN)
International Classes:
C12N5/10; A61K39/00; A61P35/00
Domestic Patent References:
WO2007063415A22007-06-07
Foreign References:
JPS61177984A1986-08-09
CN1537161A2004-10-13
CN102165057A2011-08-24
US4804627A1989-02-14
Other References:
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XU CHONGFENG, DUAN ZIYUAN: "A Supporting Role of Chinese National Immortalized Cell Bank in Life Science Research", HEREDITAS, ZHONGGUO YICHUAN XUEHUI KEXUE, BEJING, CN, vol. 39, no. 1, 1 January 2017 (2017-01-01), CN, pages 75 - 86, XP055780330, ISSN: 0253-9772, DOI: 10.16288/j.yczz.16-391
LAM, K.M.C., CRAWFORD, D.H.: "Method for generation of human B lymphoblastoid cell lines using Epstein-Barr virus.", METHODS IN CELL SCIENCE, vol. 17, no. 2, 31 December 1995 (1995-12-31), pages 67 - 74, XP009525991, DOI: 10.1007/BF00986653
LEIBOLD W, FLANAGAN T. D, MENEZES J, KLEIN G: "Brief Communication: Induction of Epstein-Barr Virus-Associated Nuclear Antigen During In Vitro Transformation of Human Lymphoid Cells.", JNCI : JOURNAL OF THE NATIONAL CANCER INSTITUTE, vol. 54, no. 1, 31 January 1975 (1975-01-31), pages 65 - 68, XP009525993, ISSN: 10.1093/jnci/54.1.65
LIU, LUYAO ET AL.: "Research Progress on the Immune Mechanism Controlling EB Virus Infection", CHINESE JOURNAL OF EVIDENCE-BASED PEDIATRICS, vol. 12, no. 3, 30 June 2017 (2017-06-30), pages 219 - 232, XP009525986, DOI: 103969 / jissn1673-5501201703012
Attorney, Agent or Firm:
BEIJING YUANBEN INTELLECTUAL PROPERTY LAW OFFICE (CN)
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