Title:
BASE EDITING SYSTEM AND USE METHOD THEREFOR
Document Type and Number:
WIPO Patent Application WO/2021/032155
Kind Code:
A1
Abstract:
Provided is a base editing fusion protein, comprising a nucleic acid targeting domain, a cytosine deaminase domain and an adenine deaminase domain. Also provided is a base editing system and a method for generating at least one genetically modified cell.
Inventors:
GAO CAIXIA (CN)
LI CHAO (CN)
LI CHAO (CN)
Application Number:
PCT/CN2020/110207
Publication Date:
February 25, 2021
Filing Date:
August 20, 2020
Export Citation:
Assignee:
INST GENETICS & DEVELOPMENTAL BIOLOGY CAS (CN)
International Classes:
C12N15/62; C07K19/00; C12N15/10; C12N15/82; C12N15/85
Domestic Patent References:
| WO2019147014A1 | 2019-08-01 |
Foreign References:
| CN110835634A | 2020-02-25 | |||
| CN109517841A | 2019-03-26 | |||
| CN109517841A | 2019-03-26 | |||
| CN109957569A | 2019-07-02 |
Other References:
LI CHAO; ZHANG RUI; MENG XIANGBING; CHEN SHA; ZONG YUAN; LU CHUNJU; QIU JIN-LONG; CHEN YU-HANG; LI JIAYANG; GAO CAIXIA: "Targeted, random mutagenesis of plant genes with dual cytosine and adenine base editors", NATURE BIOTECHNOLOGY, GALE GROUP INC., NEW YORK, US, vol. 38, no. 7, 13 January 2020 (2020-01-13), us, pages 875 - 882, XP037187539, ISSN: 1087-0156, DOI: 10.1038/s41587-019-0393-7
LIU, JIAHUI ET AL.: "Research Progress of Base Editing System", WORLD SCI-TECH R&D, vol. 39, no. 6, 31 December 2017 (2017-12-31), XP055763468, ISSN: 1006-6055, DOI: 10.16507/j.issn.1006-6055.2017.09.004
LIU, JIAHUI ET AL.: "Research Progress of Base Editing System", WORLD SCI-TECH R&D, vol. 39, no. 6, 31 December 2017 (2017-12-31), XP055763468, ISSN: 1006-6055, DOI: 10.16507/j.issn.1006-6055.2017.09.004
Attorney, Agent or Firm:
NTD UNIVATION INTELLECTUAL PROPERTY AGENCY LTD. (CN)
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