Title:
BENZAMIDE COMPOUND, INTERMEDIATES, PREPARATION METHOD, AND APPLICATION
Document Type and Number:
WIPO Patent Application WO/2020/142865
Kind Code:
A1
Abstract:
Disclosed in the present invention are a Benzamide compound, intermediates, a preparation method, and an application. The present invention provides a Benzamide compound as represented by formula I, and pharmaceutically acceptable salts, hydrates, solvates, polymorphs, metabolites, stereoisomers, tautomers, or prodrugs thereof.The Benzamide compound has an application of inducing and stimulating mesenchymal stem cells (MSCs) to differentiate into chondrocytes to repair the cartilage. Also provided are a composition and method for treating, preventing or ameliorating arthritis or joint injury by applying the compound or composition of the present invention to a joint, cartilage tissue, or proximal cartilage tissue or the whole body. The present invention also provides a composition and method for inducing MSCs to differentiate into chondrocytes.
Inventors:
JIANG QING (CN)
LE XIAOYONG (CN)
CHEN XIN (CN)
HU DAIQIANG (CN)
ZHU JIAN (CN)
LE XIAOYONG (CN)
CHEN XIN (CN)
HU DAIQIANG (CN)
ZHU JIAN (CN)
Application Number:
PCT/CN2019/070573
Publication Date:
July 16, 2020
Filing Date:
January 07, 2019
Export Citation:
Assignee:
JIANGSU KDN PHARMACEUTICAL TECH CO LTD (CN)
International Classes:
C07C327/48; A61K31/165; A61K31/426; A61P19/02; A61P19/10; C07C233/65; C07D213/16; C07D277/14
Foreign References:
| US20030055263A1 | 2003-03-20 | |||
| US20030055287A1 | 2003-03-20 | |||
| CN102477001A | 2012-05-30 | |||
| US20100305124A1 | 2010-12-02 | |||
| CN1826339A | 2006-08-30 | |||
| US4910211A | 1990-03-20 | |||
| CN105228626A | 2016-01-06 | |||
| CN1144217A | 1997-03-05 | |||
| JPH02207078A | 1990-08-16 |
Other References:
W.Q ZHOU , R.D LU , X WANG: "Theoretical Studies on Nonlinear Polarizability of Substitution Thiourea", JOURNAL OF MOLECULAR STRUCTURE THEOCHEM, vol. 624, no. 1-3, 25 April 2003 (2003-04-25), pages 123 - 127, XP027123715, ISSN: 0166-1280, DOI: 10.1016/S0166-1280(02)00753-4
KAZUHIRO KOBAYASHI, YUUHO SHIGEMURA, DAIKI FUJIWARA: "Synthesis of 3-iminobenzo[c]thiophen-1(3H)-one Derivatives Based on the Reaction of 2-lithio-N, N-dimethylbenzamides with Isothiocyanates", HETEROCYCLES, vol. 94, no. 6, 18 April 2017 (2017-04-18), pages 1152 - 1158, XP009521965, ISSN: 1881-0942, DOI: 10.3987/COM-17-13698
ROBERT J PERRY , SCOTT E TUNNEY , DAVID B WILSON: "Polyimide Formation through the Palladium-Mediated Carbonylation and Coupling of Bis(o-iodo amides) and Diamines", MACROMOLECULES, vol. 29, no. 3, 29 January 1996 (1996-01-29), pages 1014 - 1020, XP000548550, ISSN: 0024-9297, DOI: 10.1021/ma950890g
QIANG ZHANG, YOUYI PENG, WILLIAM J. WELSH: "Efficient New Approach for the Synthesis of N, N-dialkylamino-1, 2, 4-triazoles", HETEROCYCLES, vol. 68, no. 12, 2 November 2006 (2006-11-02), pages 2635 - 2645, XP009521964, ISSN: 1881-0942, DOI: 10.3987/COM-06-10886
PAN WANG, SHAN TANG , AIWEN LEI: "Electrochemical Intramolecular Dehydrogenative C-S Bond Formation for the Synthesis of Benzothiazoles", GREEN CHEMISTRY, vol. 19, no. 9, 21 March 2017 (2017-03-21), pages 2092 - 2095, XP055718620, ISSN: 1463-9262, DOI: 10.1039/c7gc00468k
KAZUHIRO KOBAYASHI, YUUHO SHIGEMURA, DAIKI FUJIWARA: "Synthesis of 3-iminobenzo[c]thiophen-1(3H)-one Derivatives Based on the Reaction of 2-lithio-N, N-dimethylbenzamides with Isothiocyanates", HETEROCYCLES, vol. 94, no. 6, 18 April 2017 (2017-04-18), pages 1152 - 1158, XP009521965, ISSN: 1881-0942, DOI: 10.3987/COM-17-13698
ROBERT J PERRY , SCOTT E TUNNEY , DAVID B WILSON: "Polyimide Formation through the Palladium-Mediated Carbonylation and Coupling of Bis(o-iodo amides) and Diamines", MACROMOLECULES, vol. 29, no. 3, 29 January 1996 (1996-01-29), pages 1014 - 1020, XP000548550, ISSN: 0024-9297, DOI: 10.1021/ma950890g
QIANG ZHANG, YOUYI PENG, WILLIAM J. WELSH: "Efficient New Approach for the Synthesis of N, N-dialkylamino-1, 2, 4-triazoles", HETEROCYCLES, vol. 68, no. 12, 2 November 2006 (2006-11-02), pages 2635 - 2645, XP009521964, ISSN: 1881-0942, DOI: 10.3987/COM-06-10886
PAN WANG, SHAN TANG , AIWEN LEI: "Electrochemical Intramolecular Dehydrogenative C-S Bond Formation for the Synthesis of Benzothiazoles", GREEN CHEMISTRY, vol. 19, no. 9, 21 March 2017 (2017-03-21), pages 2092 - 2095, XP055718620, ISSN: 1463-9262, DOI: 10.1039/c7gc00468k
Attorney, Agent or Firm:
SHANGHAI BESHINING LAW OFFICE (CN)
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