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Title:
BENZAZEPINE DERIVATIVE, PREPARATION METHOD, PHARMACEUTICAL COMPOSITION AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2017/190669
Kind Code:
A1
Abstract:
Disclosed are a benzazepine derivative, a preparation method, a pharmaceutical composition and the use thereof. The compound as shown in formula (I) of the present invention, and an isomer, a prodrug, a stable isotope derivative or a pharmaceutically acceptable salt thereof have the following structure. The benzazepine derivative of the present invention has a good regulation effect on the TLR family and the related signalling pathway, and in particular, has a very good regulation effect on TLR8, can effectively treat, relieve and/or prevent various diseases mediated by the TLR family and the TLR-related signalling pathway, and in particular, can effectively treat, relieve and/or prevent various diseases mediated by TLR8, such as cancers, autoimmune diseases, infections, inflammations, transplantation rejections, graft-versus-host diseases, etc.

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Inventors:
GAO DAXIN (CN)
WANG YUXUN (CN)
CHEN SHOUJUN (CN)
YANG HEPING (CN)
Application Number:
PCT/CN2017/083031
Publication Date:
November 09, 2017
Filing Date:
May 04, 2017
Export Citation:
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Assignee:
SHANGHAI DE NOVO PHARMATECH CO LTD (CN)
International Classes:
C07D401/04; A61K31/55; A61P29/00; A61P31/00; A61P35/00; A61P37/00; C07D401/14; C07D403/04; C07D471/04; C07D491/048; C07D495/04
Foreign References:
CN102781933A2012-11-14
CN103562186A2014-02-05
CN102753542A2012-10-24
CN201610296748A2016-05-06
CN201610589219A2016-07-25
CN201610965360A2016-11-04
CN201710020298A2017-01-12
CN201710054038A2017-01-24
Other References:
INT IMMUNOPHARMACOL, vol. 2, 2002, pages 443 - 451
BERGE ET AL.: "Pharmaceutically acceptable salts", J. PHARM. SCI., vol. 66, 1977, pages 1 - 19
Attorney, Agent or Firm:
SHANGHAI BESHINING LAW OFFICE (CN)
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