BENZENE DERIVATIVES, PROCESS FOR PREPARING THE SAME AND USE THEREOF

Title:

BENZENE DERIVATIVES, PROCESS FOR PREPARING THE SAME AND USE THEREOF

Document Type and Number:

WIPO Patent Application WO2003029199

Kind Code:

A9

Abstract:

Novel benzene derivatives represented by the general formula (||), which exhibit vanilloid receptor agonism and are useful as preventive and therapeutic drugs for pollakisuria and urinary incontinence, analgesic, or the like: (||) wherein R<1>, R<4> and R<6> are each independently hydrogen, halogeno, or hydrocarbyl; R<2> is hydrocarbyl or a heterocyclic group; R<3> is hydrocarbyl, NR<7'>R<7>, or OR<8> (wherein R<7'> is hydrogen or hydrocarbyl and R<7> is a non-aromatic group, or alternatively R<7' >and R<7> together with the nitrogen atom adjacent thereto may form a ring; and R<8> is hydrocarbyl or a heterocyclic group); R<5> is hydrocarbyl or a heterocyclic group (except quinolyl) and R<5'> is hydrogen or hydrocarbyl, or R<5> and R<5'> together with the nitrogen atom adjacent thereto may form a ring; and R<5''> is hydrogen or hydrocarbyl.

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Inventors:

MATSUMOTO TAKAHIRO (JP)
YAMAMOTO MASATAKA (JP)
NAGABUKURO HIROSHI (JP)
MOCHIZUKI MANABU (JP)

Application Number:

PCT/JP2002/009995

Publication Date:

September 25, 2003

Filing Date:

September 27, 2002

Export Citation:

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Assignee:

TAKEDA CHEMICAL INDUSTRIES LTD (JP)
MATSUMOTO TAKAHIRO (JP)
YAMAMOTO MASATAKA (JP)
NAGABUKURO HIROSHI (JP)
MOCHIZUKI MANABU (JP)

International Classes:

A61K31/17; A61K31/216; A61K31/357; A61K31/36; A61K31/4045; A61K31/4184; A61K31/42; A61K31/44; A61K31/4409; A61K31/445; A61K31/4453; A61K31/4468; A61K31/495; A61K31/55; A61K31/551; A61P1/06; A61P1/08; A61P1/14; A61P3/04; A61P3/06; A61P3/08; A61P9/00; A61P9/02; A61P9/10; A61P11/02; A61P13/02; A61P15/12; A61P17/00; A61P17/04; A61P17/06; A61P19/02; A61P25/00; A61P25/02; C07C275/38; C07C275/42; C07C309/66; C07C311/08; C07C311/21; C07C311/47; C07C317/42; C07C323/42; C07C323/44; C07C323/62; C07D207/14; C07D207/27; C07D209/08; C07D209/16; C07D211/46; C07D211/52; C07D211/58; C07D211/62; C07D213/30; C07D213/40; C07D213/56; C07D213/65; C07D213/74; C07D213/75; C07D215/08; C07D215/38; C07D217/02; C07D223/12; C07D233/54; C07D235/30; C07D261/14; C07D277/82; C07D295/13; C07D295/192; C07D295/215; C07D307/14; C07D307/52; C07D317/66; C07D321/10; C07D333/16; C07D207/26; (IPC1-7): C07C275/38; C07C275/42; C07D213/30; C07D213/40; C07D213/65; C07D213/75; C07D261/14; C07D295/20; C07D317/58; C07D317/66; C07D319/18; C07D321/10; A61K31/17; A61K31/216; A61K31/357; A61K31/36; A61K31/4045; A61K31/4184; A61K31/42; A61K31/44; A61K31/4409; A61K31/445; A61K31/4453; A61K31/4468; A61K31/495; A61K31/55; A61K31/551; A61P1/06; A61P1/08; A61P1/14; A61P3/04; A61P3/06; A61P3/08; A61P9/00; A61P9/02; A61P9/10; A61P11/02; A61P13/02; A61P15/12; A61P17/00; A61P17/04; A61P17/06; A61P19/02; A61P25/00; A61P25/02

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