Title:
BENZODIAZEPINE COMPOUND, PREPARATION METHOD THEREFOR, AND USE THEREOF IN MEDICINE
Document Type and Number:
WIPO Patent Application WO/2020/259602
Kind Code:
A1
Abstract:
Disclosed are a benzodiazepine compound, a preparation method therefor, and the use thereof in medicine, with same belonging to the chemical and pharmaceutical field. The benzodiazepine compound is a compound represented by formula I, or a salt thereof, or a stereoisomer thereof, or a solvate thereof, or an eutectic thereof, or a composition thereof. The compound has a good intravenous sedative anesthesia effect, and the anesthesia effect thereof is comparable to that of remimazolam and even better than that of remimazolam, particularly seen in that the effective dose is significantly decreased, and the duration time and recovery time are significantly reduced. At the same time, the recovery quality of the compound is significantly improved compared with remimazolam in rat and mouse caudal venous anesthesia models. During anesthetization, the compound has a rapid onset, a short duration, a quick recovery and a good tolerance, can be used for anesthesia induction, anesthesia maintenance and day surgery anesthesia, and has good application prospects.
Inventors:
KE BOWEN (CN)
LIU JIN (CN)
YANG JUN (CN)
LIU JIN (CN)
YANG JUN (CN)
Application Number:
PCT/CN2020/098160
Publication Date:
December 30, 2020
Filing Date:
June 24, 2020
Export Citation:
Assignee:
WEST CHINA HOSPITAL SICHUAN UNIV (CN)
International Classes:
C07D487/04; A61K31/5517; A61P23/00; A61P25/20
Domestic Patent References:
| WO2000069836A1 | 2000-11-23 | |||
| WO2017101808A1 | 2017-06-22 | |||
| WO2018148361A1 | 2018-08-16 | |||
| WO1996023790A1 | 1996-08-08 |
Foreign References:
| CN108033964A | 2018-05-15 |
Other References:
LIU, Y. ET AL.: "Design, Synthesis, and Biological Evaluation of Novel CNS 7056 Derivatives as Sedatives in Rats and Rabbits", CHEM BIOL DRUG DES., vol. 88, no. 1, 28 January 2016 (2016-01-28), XP055428919, DOI: 20200818185530A
See also references of EP 3992194A4
See also references of EP 3992194A4
Attorney, Agent or Firm:
GAOYUNG INTELLECTUAL PROPERTY AGENCY (GENERAL PARTNERSHIP) (CN)
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