Title:
BENZOTHIAZOLE AND BENZIMIDAZOLE DERIVATIVES, PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL COMPOSITION COMPRISING SAME AS ACTIVE INGREDIENT
Document Type and Number:
WIPO Patent Application WO/2022/164135
Kind Code:
A1
Abstract:
The present invention relates to a benzothiazole or benzimidazole derivative, a pharmaceutically acceptable salt thereof, and a pharmaceutical composition comprising same as an active ingredient for prevention or treatment of SIRTUIN 7 protein-related diseases. With excellent inhibitory activity against SIRTUIN 7 protein, the derivative can be used for preventing or treating SIRTUIN 7 protein-related diseases.
Inventors:
KIM KWANG ROK (KR)
JEONG KWAN YOUNG (KR)
JUNG HEE JUNG (KR)
KIM DOYOUN (KR)
LEE JUNMI (KR)
RLEE SANG DAL (KR)
LEE KYU MYUNG (KR)
JUNG DOO YOUNG (KR)
LEE JIN SOO (KR)
CHO HYUN YONG (KR)
JEONG KWAN YOUNG (KR)
JUNG HEE JUNG (KR)
KIM DOYOUN (KR)
LEE JUNMI (KR)
RLEE SANG DAL (KR)
LEE KYU MYUNG (KR)
JUNG DOO YOUNG (KR)
LEE JIN SOO (KR)
CHO HYUN YONG (KR)
Application Number:
PCT/KR2022/001117
Publication Date:
August 04, 2022
Filing Date:
January 21, 2022
Export Citation:
Assignee:
KOREA RES INST CHEMICAL TECH (KR)
PINOTBIO INC (KR)
PINOTBIO INC (KR)
International Classes:
C07D235/30; A61K31/4355; A61K31/496; A61K31/501; A61K31/506; A61P35/00; C07D235/32; C07D277/82; C07D403/12; C07D417/12
Domestic Patent References:
| WO2010024903A1 | 2010-03-04 |
Foreign References:
| KR20050043912A | 2005-05-11 | |||
| KR20200043433A | 2020-04-27 | |||
| KR20150101656A | 2015-09-04 | |||
| US20100196368A1 | 2010-08-05 |
Other References:
KIRAN ET AL., FEBS J, 2013
HUBBI ET AL., J BIOL CHEM, 2013
CHEN ET AL., MOLCELL, 2013
SHIN ET AL., CELL REP, 2013
VAKHRUSHEVA ET AL., CIRC RES, 2008
RYU ET AL., CELL METABOLISM, 2014
LEE ET AL., PROTEOMICS, 2014
GHIRALDINI ET AL., MOL BIOLCELL, 2013
VAKHRUSHEVA ET AL., J PHYSIOL PHARMACOL, 2008
VAKHRUSHEVA ET AL., CIR RES, 2008
MAO ET AL., SCIENCE, 2011
KIRAN ET AL., EXP CELL RES, 2014
BARBER ET AL., NATURE, 2012
KIM ET AL., HEPATOLOGY, 2013
DE NIGRIS ET AL., BR J CANCER, 2002
ASHRAF ET AL., BR J CANCER, 2006
BIOCHEM BIOPHYS RES COMMUN., vol. 508, 2019, pages 451 - 457
HUBBI ET AL., J BIOL CHEM, 2013
CHEN ET AL., MOLCELL, 2013
SHIN ET AL., CELL REP, 2013
VAKHRUSHEVA ET AL., CIRC RES, 2008
RYU ET AL., CELL METABOLISM, 2014
LEE ET AL., PROTEOMICS, 2014
GHIRALDINI ET AL., MOL BIOLCELL, 2013
VAKHRUSHEVA ET AL., J PHYSIOL PHARMACOL, 2008
VAKHRUSHEVA ET AL., CIR RES, 2008
MAO ET AL., SCIENCE, 2011
KIRAN ET AL., EXP CELL RES, 2014
BARBER ET AL., NATURE, 2012
KIM ET AL., HEPATOLOGY, 2013
DE NIGRIS ET AL., BR J CANCER, 2002
ASHRAF ET AL., BR J CANCER, 2006
BIOCHEM BIOPHYS RES COMMUN., vol. 508, 2019, pages 451 - 457
Attorney, Agent or Firm:
B&IP-JOOWON PATENT AND LAW FIRM (KR)
Download PDF: