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Title:
BETA-AMINO ACID DERIVATIVES AS INHIBITORS OF MATRIX METALLOPROTEASES AND TNF-ALPHA
Document Type and Number:
WIPO Patent Application WO2001070734
Kind Code:
A3
Abstract:
The present application describes novel β-amino acid derivatives of formula (I) or pharmaceutically acceptable salt or prodrug forms thereof, wherein A, X, Z, U, X, Y, Z, R<1>, R<2>, R<3>, R<4>, and R<4a> are defined in the present specification, which are useful as metalloprotease and as TNF-α inhibitors.

Inventors:
DUAN JINGWU
KING BRYAN W
DECICCO CARL
MADUSKUIE THOMAS P JR
VOSS MATTHEW E
Application Number:
PCT/US2001/008336
Publication Date:
March 14, 2002
Filing Date:
March 15, 2001
Export Citation:
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Assignee:
DU PONT PHARM CO (US)
International Classes:
A61K31/445; A61K31/4468; A61K31/4545; A61K31/47; A61K31/4709; A61K31/541; A61K31/55; A61P1/02; A61P1/04; A61P1/14; A61P1/16; A61P7/02; A61P7/04; A61P9/00; A61P9/04; A61P11/00; A61P11/06; A61P17/00; A61P17/02; A61P17/06; A61P19/00; A61P19/02; A61P19/04; A61P19/06; A61P19/08; A61P21/00; A61P21/04; A61P25/28; A61P25/32; A61P27/02; A61P27/06; A61P29/00; A61P31/04; A61P31/18; A61P33/02; A61P35/00; A61P35/04; A61P37/00; A61P37/02; A61P39/00; A61P41/00; A61P43/00; C07D211/34; C07D211/58; C07D215/14; C07D401/06; C07D401/12; C07D401/14; C07D405/12; C07D405/14; C07D409/12; C07D413/12; C07D417/12; C07D417/14; C07D451/04; C07D455/02; (IPC1-7): C07D401/12; C07D211/34; C07D215/14; C07D417/12; C07D405/12; C07D401/06; C07D401/14; C07D211/58; C07D409/12; C07D405/14; A61K31/4545; A61P29/00
Domestic Patent References:
WO1997020824A11997-06-12
Foreign References:
EP0818442A21998-01-14
EP0376166A11990-07-04
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