Title:
BI-HETEROCYCLIC NUCLEOCAPSID INHIBITOR AND PHARMACEUTICAL USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2019/210879
Kind Code:
A1
Abstract:
The present invention relates to a bicyclic nucleocapsid inhibitor and use thereof as a drug for treating hepatitis B. Specifically, disclosed is a compound which can be used as an HBV inhibitor and has a structure represented by chemical formula (A), or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt, hydrate, or solvate thereof. The definition of each group is detailed in the description. The present invention also relates to a pharmaceutical composition containing the compound and use thereof in treating hepatitis B.
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Inventors:
WANG ZHE (CN)
ZENG ZHIHONG (CN)
ZENG ZHIHONG (CN)
Application Number:
PCT/CN2019/085558
Publication Date:
November 07, 2019
Filing Date:
May 05, 2019
Export Citation:
Assignee:
SHANGHAI LONGWOOD BIOPHARMACEUTICALS CO LTD (CN)
International Classes:
C07D209/52; A61K31/403; A61K31/454; A61P31/20; C07D401/12; C07D403/12; C07D405/12; C07D405/14; C07D413/12; C07D413/14; C07D451/06
Domestic Patent References:
| WO2017198744A1 | 2017-11-23 | |||
| WO2018052967A1 | 2018-03-22 | |||
| WO2016109663A2 | 2016-07-07 |
Foreign References:
| CN108794487A | 2018-11-13 | |||
| CN108341817A | 2018-07-31 | |||
| CN105102451A | 2015-11-25 |
Attorney, Agent or Firm:
XU & PARTNERS, LLC. (CN)
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