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Patent Searching and Data


Title:
BIARYL COMPOUND, PREPARATION METHOD AND USE THEREFOR
Document Type and Number:
WIPO Patent Application WO/2018/145653
Kind Code:
A1
Abstract:
The present invention relates to the technical field of chemical medicine and relates to a compound represented by formula (I) or formula (II) and a preparation method therefor, the compound being a biaryl derivative and having retinoid-related orphan receptor (RORγt) agonist activity. The biaryl derivative disclosed in the present invention may effectively activate a RORγt protein receptor, thereby promoting the differentiation of T Helper 17 (Th17) cells and increasing the production of interleukin-17 (IL-17); as an immunomodulator, the biaryl derivative is suitable for the treatment of a plurality of cancers or virological infectious diseases.

Inventors:
WANG YONGHUI (CN)
HUANG YAFEI (CN)
QIU RUOMENG (CN)
TANG TING (CN)
Application Number:
PCT/CN2018/075905
Publication Date:
August 16, 2018
Filing Date:
February 09, 2018
Export Citation:
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Assignee:
UNIV FUDAN (CN)
International Classes:
C07C253/30; A61K31/277; A61P31/12; C07C255/58; C07C255/60; C07C317/44; C07D213/56; C07D213/64; C07D231/12; C07D309/04
Domestic Patent References:
WO2013171729A22013-11-21
WO2016193470A12016-12-08
WO2013029338A12013-03-07
WO2015070091A12015-05-14
Foreign References:
CN105272904A2016-01-27
CN103998032A2014-08-20
JP2016108257A2016-06-20
Other References:
See also references of EP 3581561A4
Attorney, Agent or Firm:
SUNRAY INTELLECTUAL PROPERTY ATTORNEYS (CN)
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