Title:
BIFIDOBACTERIA REGULATING EXPRESSION OF CLOCK GENE
Document Type and Number:
WIPO Patent Application WO/2022/118525
Kind Code:
A1
Abstract:
[Problem] To provide a method for effectively regulating an expression of a clock gene, and in particular, to provide a method of promoting the transcription of Per2 gene which plays a key role in circadian rhythm formation. [Solution] The present invention is characterized in that bifidobacteria are longum species of the genus bifidobacterium which regulates an expression of a clock gene. In addition, the present invention is characterized in that the bifidobacteria are bifidobacterium longum strain N576 (NITE BP-03308). Moreover, the present invention is characterized in that a food or beverage contains the bifidobacteria.
Inventors:
OKADA MOTOHIRO (JP)
NAGASAKI YASUHISA (JP)
OKI ATSUSHI (JP)
NAGASAKI YASUHISA (JP)
OKI ATSUSHI (JP)
Application Number:
PCT/JP2021/035381
Publication Date:
June 09, 2022
Filing Date:
September 27, 2021
Export Citation:
Assignee:
NISSIN FOODS HOLDINGS CO LTD (JP)
International Classes:
C12N1/20; A23L33/135
Foreign References:
| JP2013181005A | 2013-09-12 | |||
| JP2008179573A | 2008-08-07 |
Other References:
GUAL-GRAU, A.; BOQUÉ, N.; BLADÉ, C.; AROLA, L. : "051 The Intestinal Microbiota Composition is Influenced by Circadian Rhythms in 344 Fiscer Rats", ANNALS OF NUTRITION & METABOLISM, vol. 73, no. Suppl. 2, 1 June 2018 (2018-06-01), pages 47, XP009537202
BOWERS S. J., PEREZ S., OWENS W.A., GREEN A., REDUS L., PARROTT J.M., DELGADO J.N., DAWS L.C., LODGE D.J.: "Disruption of the gut microbiome with oral antibiotic reduces core body temperature and disrupts diurnal rhythms of locomotor activity, but not sleep, in rats", BRAIN, BEHAVIOR AND IMMUNITY, vol. 40, 1 January 2014 (2014-01-01), US , pages e43, XP055937240, ISSN: 0889-1591, DOI: 10.1016/j.bbi.2014.06.167
BOWERS S. J., PEREZ S., OWENS W.A., GREEN A., REDUS L., PARROTT J.M., DELGADO J.N., DAWS L.C., LODGE D.J.: "Disruption of the gut microbiome with oral antibiotic reduces core body temperature and disrupts diurnal rhythms of locomotor activity, but not sleep, in rats", BRAIN, BEHAVIOR AND IMMUNITY, vol. 40, 1 January 2014 (2014-01-01), US , pages e43, XP055937240, ISSN: 0889-1591, DOI: 10.1016/j.bbi.2014.06.167
Attorney, Agent or Firm:
UENO, Hideki (JP)
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