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Title:
BIODEGRADABLE HYDROGEL HAVING CYCLIC BENZYLIDENE ACETAL STRUCTURE
Document Type and Number:
WIPO Patent Application WO/2017/170705
Kind Code:
A1
Abstract:
Provided is a biodegradable hydrogel having an acetal structure, the hydrolysis rate of which is able to be accurately controlled in different in vivo pH environments. A hydrogel which is obtained by crosslinking a polyalkylene glycol derivative having a cyclic benzylidene acetal structure, said derivative being represented by formula (1), by means of a crosslinking agent. In formula (1), each of R1 and R6 independently represents a hydrogen atom or a hydrocarbon group; each of R2, R3, R4 and R5 independently represents an electron-withdrawing or electron-donating substituent or a hydrogen atom; s is 1 or 2, t is 0 or 1, and (s + t) is 1 or 2; P1 represents a polyalkylene glycol having 2-8 terminals; each of Z1 and Z2 independently represents a divalent spacer; W1 is equal to the number of terminals of the polyalkylene glycol, said number being an integer of 2-8; and X1 represents a chemically reactive functional group.

Inventors:
TSUBUSAKI TAKUMA (JP)
SHISHIDO MIKA (JP)
Application Number:
PCT/JP2017/012925
Publication Date:
October 05, 2017
Filing Date:
March 29, 2017
Export Citation:
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Assignee:
NOF CORP (JP)
International Classes:
C08G65/333; A61K47/22; A61K47/34; C08K5/00; C08L71/02; C08L77/04
Domestic Patent References:
WO2015152182A12015-10-08
Foreign References:
JP2001518528A2001-10-16
JPH05279416A1993-10-26
JP2006524742A2006-11-02
JP2008531011A2008-08-14
Other References:
See also references of EP 3438155A4
Attorney, Agent or Firm:
Shin-Ei Patent Firm, P. C. (JP)
Patent business corporation Shin-Ei Patent Firm (JP)
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