BIOSYNTHESIS OF COMPOUNDS IN YEAST

Title:

BIOSYNTHESIS OF COMPOUNDS IN YEAST

Document Type and Number:

WIPO Patent Application WO/2020/106870

Kind Code:

A3

Abstract:

Provided herein are genetically modified yeast cells capable of producing one or more human milk oligosaccharides. The yeast cells include one or more heterologous nucleic acids that encode enzymes of a human milk oligosaccharide biosynthetic pathway. The yeast cells do not include a heterologous nucleic acid encoding a fucokinase. Also provided are fermentation compositions including the disclosed genetically modified yeast cells, and related methods of producing and recovering human milk oligosaccharides generated by the yeast cells.

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Inventors:

WALTER JESSICA (US)
LERMAN JOSHUA (US)
LEAVELL MICHAEL (US)
YAP BENJAMIN (US)

Application Number:

PCT/US2019/062454

Publication Date:

July 30, 2020

Filing Date:

November 20, 2019

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Assignee:

AMYRIS INC (US)

International Classes:

C07H13/04

Domestic Patent References:

WO2005055944A2	2005-06-23
WO2016075243A1	2016-05-19
WO2010036898A1	2010-04-01
WO2014090261A1	2014-06-19

Other References:

JING-JING LIU ET AL: "-Fucose Using Engineered Saccharomyces cerevisiae", ACS SYNTHETIC BIOLOGY, 24 October 2018 (2018-10-24), Washington, DC,USA, XP055521878, ISSN: 2161-5063, DOI: 10.1021/acssynbio.8b00134
NAM SOO HAN ET AL: "Biotechnological production of human milk oligosaccharides", BIOTECHNOLOGY ADVANCES, vol. 30, no. 6, 1 November 2012 (2012-11-01), pages 1268 - 1278, XP055074947, ISSN: 0734-9750, DOI: 10.1016/j.biotechadv.2011.11.003

Attorney, Agent or Firm:

MOUSSA, Akkad, Y. et al. (US)

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