Title:
BIPHENYL COMPOUND AS IMMUNOMODULATOR, PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/161421
Kind Code:
A1
Abstract:
A biphenyl compound as shown in formula (I), a preparation method therefor and use thereof, and a pharmaceutical composition comprising the compound as an active ingredient. The compound is a novel small-molecule immunomodulator having excellent oral absorption characteristics, and can be used for treating and/or preventing various immune-related diseases.
Inventors:
YANG QIANJIAO (CN)
SHAN SONG (CN)
XIN LIJUN (CN)
PAN DESI (CN)
WANG XIAOLIANG (CN)
SONG YONGLIAN (CN)
HUANG HUIYUN (CN)
WEI QI (CN)
LI ZHIBIN (CN)
LU XIANPING (CN)
SHAN SONG (CN)
XIN LIJUN (CN)
PAN DESI (CN)
WANG XIAOLIANG (CN)
SONG YONGLIAN (CN)
HUANG HUIYUN (CN)
WEI QI (CN)
LI ZHIBIN (CN)
LU XIANPING (CN)
Application Number:
PCT/CN2022/074183
Publication Date:
August 04, 2022
Filing Date:
January 27, 2022
Export Citation:
Assignee:
SHENZHEN CHIPSCREEN BIOSCIENCES CO LTD (CN)
International Classes:
C07D471/04; A61K31/437; A61P35/00; A61P37/00; C07C211/50; C07D403/14; C07D519/00
Domestic Patent References:
| WO2019217821A1 | 2019-11-14 | |||
| WO2018106850A1 | 2018-06-14 | |||
| WO2019217821A1 | 2019-11-14 |
Foreign References:
| CN110267953A | 2019-09-20 | |||
| CN109020958A | 2018-12-18 | |||
| CN110267953A | 2019-09-20 |
Other References:
COUZIN-FRANKEL J., SCIENCE, vol. 342, 2013, pages 1432 - 1433
MELLMAN I.COUKOS G.DRANOFF G., NATURE, vol. 480, 2011, pages 480 - 489
CHENG X.VEVERKA VRADHAKRISHNAN A. ET AL., J. BIOL. CHEM., vol. 288, 2013, pages 11771 - 11785
FULLER M.J.CALLENDRET B.ZHU B. ET AL., PROC. NATL USA, vol. 110, 2013, pages 15001 - 15006
DOLAN D.E.GUPTA S., CANCER CONTROL, vol. 21, 2014, pages 231 - 237
CHEN L.HAN X., J. CLIN. INVEST., vol. 125, 2015, pages 3384 - 3391
POSTOW M.A.CALLAHAN M.K.WOLCHOK J.D., J. CLIN. ONCOL., vol. 33, 2015, pages 1974 - 1982
SUGIURA D.MARUHASHI T.OKAZAKI 11-MI ET AL., SCIENCE, vol. 364, 2019, pages 558 - 566
MELLMAN I.COUKOS G.DRANOFF G., NATURE, vol. 480, 2011, pages 480 - 489
CHENG X.VEVERKA VRADHAKRISHNAN A. ET AL., J. BIOL. CHEM., vol. 288, 2013, pages 11771 - 11785
FULLER M.J.CALLENDRET B.ZHU B. ET AL., PROC. NATL USA, vol. 110, 2013, pages 15001 - 15006
DOLAN D.E.GUPTA S., CANCER CONTROL, vol. 21, 2014, pages 231 - 237
CHEN L.HAN X., J. CLIN. INVEST., vol. 125, 2015, pages 3384 - 3391
POSTOW M.A.CALLAHAN M.K.WOLCHOK J.D., J. CLIN. ONCOL., vol. 33, 2015, pages 1974 - 1982
SUGIURA D.MARUHASHI T.OKAZAKI 11-MI ET AL., SCIENCE, vol. 364, 2019, pages 558 - 566
Attorney, Agent or Firm:
UNITALEN ATTORNEYS AT LAW (CN)
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