Title:
BIPHENYL DERIVATIVES
Document Type and Number:
WIPO Patent Application WO/2002/051799
Kind Code:
A1
Abstract:
Biphenyl derivatives represented by the general formula (1) or salts thereof; and ACAT inhibitors or medicines containing the same as the active ingredient: (1) [wherein R?1¿ is C¿5-7? alkyl; R?2¿ is optionally substituted aromatic hydrocarbyl or cyclcoalkyl; R?3¿ is tetrazolyl, -NHCOCF¿3?, -NHSO¿2?CF¿3?, or SO¿2?NHCONHR?4¿ (wherein R?4¿ is optionally substituted aromatic hydrocarbyl); and Z is a single bond, C¿1-4? alkylene, or SO¿2?NH-]. The derivatives and the salts have excellent ACAT inhibiting activity and are useful as preventive and/or therapeutic drugs for diseases due to the rise in ACAT activity, e.g., hypercholesterolemia and atherosclerosis.
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Inventors:
NAMIKI TAKAYUKI (JP)
KISHII KENICHI (JP)
MITANI MASAKI (JP)
TAMAI MASASHI (JP)
HIYAMA NAOKI (JP)
KIMURA MAKOTO (JP)
ICHINOMIYA SATOSHI (JP)
KISHII KENICHI (JP)
MITANI MASAKI (JP)
TAMAI MASASHI (JP)
HIYAMA NAOKI (JP)
KIMURA MAKOTO (JP)
ICHINOMIYA SATOSHI (JP)
Application Number:
PCT/JP2001/010626
Publication Date:
July 04, 2002
Filing Date:
December 05, 2001
Export Citation:
Assignee:
POLA CHEM IND INC (JP)
NAMIKI TAKAYUKI (JP)
KISHII KENICHI (JP)
MITANI MASAKI (JP)
TAMAI MASASHI (JP)
HIYAMA NAOKI (JP)
KIMURA MAKOTO (JP)
ICHINOMIYA SATOSHI (JP)
NAMIKI TAKAYUKI (JP)
KISHII KENICHI (JP)
MITANI MASAKI (JP)
TAMAI MASASHI (JP)
HIYAMA NAOKI (JP)
KIMURA MAKOTO (JP)
ICHINOMIYA SATOSHI (JP)
International Classes:
A61P3/06; A61P9/10; A61P43/00; C07C275/30; C07C311/09; C07C311/60; C07D257/04; (IPC1-7): C07C275/30; C07C311/09; C07C311/60; C07D257/04; A61K31/41; A61K31/17; A61K31/18; A61K31/54; A61K31/166; A61K31/167; A61P43/00; A61P3/06; A61P9/10
Domestic Patent References:
WO1999012534A1 | 1999-03-18 |
Foreign References:
JPH06211814A | 1994-08-02 | |||
JPH0748360A | 1995-02-21 |
Other References:
See also references of EP 1354871A4
Attorney, Agent or Firm:
Aruga, Mitsuyuki (3-6 NIHONBASHININGYOCHO 1-CHOME CHUO-KU, Tokyo, JP)
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