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Title:
BIPHENYL DERIVATIVES
Document Type and Number:
WIPO Patent Application WO/2002/051799
Kind Code:
A1
Abstract:
Biphenyl derivatives represented by the general formula (1) or salts thereof; and ACAT inhibitors or medicines containing the same as the active ingredient: (1) [wherein R?1¿ is C¿5-7? alkyl; R?2¿ is optionally substituted aromatic hydrocarbyl or cyclcoalkyl; R?3¿ is tetrazolyl, -NHCOCF¿3?, -NHSO¿2?CF¿3?, or SO¿2?NHCONHR?4¿ (wherein R?4¿ is optionally substituted aromatic hydrocarbyl); and Z is a single bond, C¿1-4? alkylene, or SO¿2?NH-]. The derivatives and the salts have excellent ACAT inhibiting activity and are useful as preventive and/or therapeutic drugs for diseases due to the rise in ACAT activity, e.g., hypercholesterolemia and atherosclerosis.

Inventors:
NAMIKI TAKAYUKI (JP)
KISHII KENICHI (JP)
MITANI MASAKI (JP)
TAMAI MASASHI (JP)
HIYAMA NAOKI (JP)
KIMURA MAKOTO (JP)
ICHINOMIYA SATOSHI (JP)
Application Number:
PCT/JP2001/010626
Publication Date:
July 04, 2002
Filing Date:
December 05, 2001
Export Citation:
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Assignee:
POLA CHEM IND INC (JP)
NAMIKI TAKAYUKI (JP)
KISHII KENICHI (JP)
MITANI MASAKI (JP)
TAMAI MASASHI (JP)
HIYAMA NAOKI (JP)
KIMURA MAKOTO (JP)
ICHINOMIYA SATOSHI (JP)
International Classes:
A61P3/06; A61P9/10; A61P43/00; C07C275/30; C07C311/09; C07C311/60; C07D257/04; (IPC1-7): C07C275/30; C07C311/09; C07C311/60; C07D257/04; A61K31/41; A61K31/17; A61K31/18; A61K31/54; A61K31/166; A61K31/167; A61P43/00; A61P3/06; A61P9/10
Domestic Patent References:
WO1999012534A11999-03-18
Foreign References:
JPH06211814A1994-08-02
JPH0748360A1995-02-21
Other References:
See also references of EP 1354871A4
Attorney, Agent or Firm:
Aruga, Mitsuyuki (3-6 NIHONBASHININGYOCHO 1-CHOME CHUO-KU, Tokyo, JP)
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