Title:
BRADYRHIZOBIUM MONOOXYGENASE AND APPLICATION THEREOF IN PREPARATION OF CHIRAL SULFOXIDE
Document Type and Number:
WIPO Patent Application WO/2019/169695
Kind Code:
A1
Abstract:
A bradyrhizobium monooxygenase, a gene for encoding the monooxygenase, a recombinant expression vector comprising the gene, a recombinant expression transformant, a method for preparing the monooxygenase by using the recombinant expression transformant, an application of the monooxygenase in preparation of optically pure chiral sulfoxide, and in particular, a method for preparing a prazole drug by catalyzing asymmetric oxidation of sulfur ether, a prazole precursor.
Inventors:
YU HUILEI (CN)
ZHANG YAN (CN)
XU JIANHE (CN)
ZHAO QIAN (CN)
PAN JIANG (CN)
LIU FENG (CN)
LIN GUOQIANG (CN)
ZHANG YAN (CN)
XU JIANHE (CN)
ZHAO QIAN (CN)
PAN JIANG (CN)
LIU FENG (CN)
LIN GUOQIANG (CN)
Application Number:
PCT/CN2018/083060
Publication Date:
September 12, 2019
Filing Date:
April 13, 2018
Export Citation:
Assignee:
UNIV EAST CHINA SCIENCE & TECH (CN)
JIANGSU AOSAIKANG PHARM CO LTD (CN)
JIANGSU AOSAIKANG PHARM CO LTD (CN)
International Classes:
C12N1/20; C12N9/02; C12N15/53; C12P11/00; C12P17/10; C12P17/16; C12R1/01
Foreign References:
CN104560905A | 2015-04-29 |
Other References:
DATABASE Protein 12 May 2017 (2017-05-12), "NAD(P)/FAD-dependent oxidoreductase [Bradyrhizobium oligotrophicum", XP055638339, retrieved from NCBI Database accession no. WP_015665598.1
LI, AITAO: "Screening and Utilization of Sulfide Monooxygenase Producting Strains", CHINESE DOCTORAL DISSERTATIONS FULL-TEXT DATABASE, 30 December 2011 (2011-12-30)
LI, AITAO: "Screening and Utilization of Sulfide Monooxygenase Producting Strains", CHINESE DOCTORAL DISSERTATIONS FULL-TEXT DATABASE, 30 December 2011 (2011-12-30)
Attorney, Agent or Firm:
BEIJING EAST LINDEN IP CO., LTD. (CN)
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