BRANCHED HETERO TYPE MONODISPERSED POLYETHYLENE GLYCOL, METHOD FOR PRODUCING SAME AND CONJUGATE OF SAME

WIPO Patent Application WO/2018/066692

A1

A branched hetero type monodispersed polyethylene glycol represented by formula (1). (In the formula, each of X1 and Y1 represents an atomic group which contains at least a functional group that forms a covalent bond by reacting with a functional group present in a biologically functional molecule, and the functional group contained in the atomic group X1 and the functional group contained in the atomic group Y1 are different from each other; n is an integer of 6-30 which represents the number of repeating units of the monodispersed polyethylene glycol; E represents a branching moiety which has a divalent bonding valance with respect to L2, while having a monovalent bonding valance with respect to L3, and which is a glycerol moiety; each of L1 and L2 independently represents a single bond or a divalent organic group; L3 represents a single bond, -L4-(CH2)m1- or -L4-(CH2)m2-L5-(CH2)m3-; L4 represents an ether bond, an amide bond or a urethane bond; L5 represents an amide bond or a urethane bond; and each of m1, m2 and m3 independently represents an integer of 1-5.)

KINBARA KAZUSHI (JP)
URUGA TOMOKI (JP)
OHTAKE TOMOYUKI (JP)

PCT/JP2017/036479

April 12, 2018

October 06, 2017

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TOKYO INST TECH (JP)
NOF CORP (JP)

C08G65/329; A61K47/68

WO2011162252A1

2011-12-29

JP2007538111A	2007-12-27
JP2005508421A	2005-03-31
US20130052130A1	2013-02-28
CN104530415A	2015-04-22

TOXINS, vol. 3, 2011, pages 848 - 883
J. MED. CHEM., vol. 54, 2011, pages 3606 - 3623
POLYM. CHEM., vol. 7, 2016, pages 2389 - 2394
See also references of EP 3524631A4

SHIN-EI PATENT FIRM, P.C. (JP)

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