Title:
BRIDGED BICYCLIC COMPOUNDS AS BTK INHIBITORS
Document Type and Number:
WIPO Patent Application WO/2022/037650
Kind Code:
A1
Abstract:
Provided herein are bridged bicyclic Compounds A and B or their pharmaceutically acceptable salts, which are as inhibitors of Bruton's tyrosine kinase (BTK) and its C481 mutant. Also provided are methods for preparing Compounds A and B or their pharmaceutically acceptable salts thereof. Compounds A and B can be used to treat and/or prevent related diseases mediated by BTK or its C481 mutant, especially cancer and autoimmune diseases.
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Inventors:
CHEN XIANGYANG (CN)
PANG YUCHENG (CN)
PANG YUCHENG (CN)
Application Number:
PCT/CN2021/113538
Publication Date:
February 24, 2022
Filing Date:
August 19, 2021
Export Citation:
Assignee:
BEIJING INNOCARE PHARMA TECH CO LTD (CN)
International Classes:
C07D253/00; A61K31/41; A61K31/53; A61P19/08; A61P29/00; A61P31/00; A61P35/00; A61P37/00; C07D255/00; C07D487/04
Domestic Patent References:
| WO2016106623A1 | 2016-07-07 | |||
| WO2016106624A1 | 2016-07-07 | |||
| WO2016106652A1 | 2016-07-07 |
Other References:
GAO XIAOLEI, WANG JAMES, LIU JIAN, GUIADEEN DEODIAL, KRIKORIAN ARTO, BOGA SOBHANA BABU, ALHASSAN ABDUL-BASIT, SELYUTIN OLEG, YU WE: "Discovery of novel BTK inhibitors with carboxylic acids", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 27, no. 6, 1 March 2017 (2017-03-01), AMSTERDAM, NL , pages 1471 - 1477, XP055902290, ISSN: 0960-894X, DOI: 10.1016/j.bmcl.2016.11.079
Attorney, Agent or Firm:
INTELIGHT IP LAW FIRM (CN)
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