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Title:
BRIDGED COMPOUNDS AS KRAS G12D INHIBITOR AND DEGRADER AND THE USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/148422
Kind Code:
A1
Abstract:
Provided herein are Bridged Compounds having the following structures: (I) wherein R 1a, R 1b, R 1c, R 1d, R 2a, R 2b, R 2c, R 2d, R 3a, R 3b, R 3c, R 3d, R 4, R 5, R 6, R 7, R 8, m1, m2, m3, n2, n3, n4, q, X 1, X 2, Y 1, Y 2, L 1 and ring A are as defined herein, compositions comprising an effective amount of a Bridged Compound, and methods for treating or preventing various diseases, e.g., pancreatic cancer, or a condition treatable or preventable by inhibition of the function of KRAS protein. In another aspect, a Bridged Compound is useful for treating or preventing a condition treatable or preventable by inhibition of the function of KRAS protein with G12D mutation. In another aspect, a Bridged Compound is useful for treating or preventing a condition treatable or preventable by inhibition of a RAS/MAPK pathway.

Inventors:
JI QI (CN)
YU CHAO (CN)
WANG CE (CN)
SUN HANZI (CN)
YUAN HAO (CN)
WANG ZHIWEI (CN)
Application Number:
PCT/CN2022/070676
Publication Date:
July 14, 2022
Filing Date:
January 07, 2022
Export Citation:
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Assignee:
BEIGENE LTD (GB)
JI QI (CN)
International Classes:
C07D487/08; A61K31/517; A61P35/00; C07D498/08
Domestic Patent References:
WO2021107160A12021-06-03
WO2021106231A12021-06-03
WO2021031952A12021-02-25
WO2017172979A12017-10-05
WO2020216190A12020-10-29
Foreign References:
CN110869358A2020-03-06
Attorney, Agent or Firm:
WU, FENG & ZHANG (CN)
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