Title:
BRIDGED NUCLEOSIDE AND NUCLEOTIDE USING SAME
Document Type and Number:
WIPO Patent Application WO/2021/167029
Kind Code:
A1
Abstract:
Disclosed is a bridged nucleoside and a nucleotide using the same. The nucleoside according to the present invention is represented by formula (I). The bridged nucleoside of the present invention is usable as a substitute for a phosphorothioate-modified nucleic acid with concerns of accumulation in a specific organ. Also, this bridged nucleoside has high industrial productivity.
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Inventors:
OBIKA SATOSHI (JP)
YAMAGUCHI TAKAO (JP)
KOMINE HIBIKI (JP)
SUGIURA TAKAYA (JP)
INOUE TAKAO (JP)
YOSHIDA TOKUYUKI (JP)
YAMAGUCHI TAKAO (JP)
KOMINE HIBIKI (JP)
SUGIURA TAKAYA (JP)
INOUE TAKAO (JP)
YOSHIDA TOKUYUKI (JP)
Application Number:
PCT/JP2021/006222
Publication Date:
August 26, 2021
Filing Date:
February 18, 2021
Export Citation:
Assignee:
UNIV OSAKA (JP)
JAPAN AS REPRESENTED BY DIRECTOR GENERAL OF NAT INSTITUTE OF HEALTH SCIENCES (JP)
JAPAN AS REPRESENTED BY DIRECTOR GENERAL OF NAT INSTITUTE OF HEALTH SCIENCES (JP)
International Classes:
C07H19/06; C07H21/00; C12N15/09
Domestic Patent References:
| WO2015125783A1 | 2015-08-27 | |||
| WO2018155451A1 | 2018-08-30 | |||
| WO2017119463A1 | 2017-07-13 | |||
| WO2020027227A1 | 2020-02-06 | |||
| WO2019009298A1 | 2019-01-10 | |||
| WO2009006478A2 | 2009-01-08 | |||
| WO2015125783A1 | 2015-08-27 |
Other References:
S. OBIKA ET AL., T. TETRAHEDRON LETT., vol. 38, 1997, pages 8735 - 8738
S. SINGH ET AL., J. CHEM. COMMUN., 1998, pages 455 - 456
E. SWAYZE ET AL., NUCLEIC ACIDS RES., vol. 35, 2007, pages 687 - 700
P.P. SETH ET AL., J. ORG. CHEM., vol. 75, 2010, pages 1569 - 1581
YAMAGUCHI, T. ET AL., CHEM. COMMUN., vol. 51, no. 51, 2015, pages 9737 - 9740
M. KUWAHARA ET AL., NUCLEIC ACIDS RES., vol. 36, no. 13, 2008, pages 4257 - 4265
S. SINGH ET AL., J. CHEM. COMMUN., 1998, pages 455 - 456
E. SWAYZE ET AL., NUCLEIC ACIDS RES., vol. 35, 2007, pages 687 - 700
P.P. SETH ET AL., J. ORG. CHEM., vol. 75, 2010, pages 1569 - 1581
YAMAGUCHI, T. ET AL., CHEM. COMMUN., vol. 51, no. 51, 2015, pages 9737 - 9740
M. KUWAHARA ET AL., NUCLEIC ACIDS RES., vol. 36, no. 13, 2008, pages 4257 - 4265
Attorney, Agent or Firm:
NAKAMICHI, Yoshihiro et al. (JP)
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