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Title:
BRIDGED RING PYRIDAZINE COMPOUND AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2024/109922
Kind Code:
A1
Abstract:
Disclosed are a bridged ring pyridazine compound and the use thereof, which compound and use belong to the technical field of chemical medicine. Provided is a bridged ring pyridazine compound as represented by formula I, which compound can be used as an NLRP3 inhibitor, and has high activity and good pharmacokinetic properties.

Inventors:
JIA TAO (CN)
WANG TAIJIN (CN)
HUANG HAO (CN)
LI GANG (CN)
CHEN LIJUAN (CN)
Application Number:
PCT/CN2023/133933
Publication Date:
May 30, 2024
Filing Date:
November 24, 2023
Export Citation:
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Assignee:
CHENGDU ZENITAR BIOMEDICAL TECH CO LTD (CN)
International Classes:
C07D237/26; A61K31/502; A61K31/5025; A61K31/504; A61P5/00; A61P9/00; A61P29/00; A61P37/02; C07D401/12; C07D405/12; C07D471/02; C07D487/04
Domestic Patent References:
WO2022216971A12022-10-13
Foreign References:
CN107163086A2017-09-15
CN115433163A2022-12-06
TW202319055A2023-05-16
CN116410140A2023-07-11
Other References:
KARAKI FUMIKA, KIGUCHI TAKUTO, ITOH KENNOSUKE, SATO NORIKO, KONISHI KAZUHIDE, FUJII HIDEAKI: "Catalyst-free photooxidation reaction from 1,4-dihydropyridazine to pyridazine under air", TETRAHEDRON, ELSEVIER SIENCE PUBLISHERS, AMSTERDAM, NL, vol. 97, 1 September 2021 (2021-09-01), AMSTERDAM, NL , pages 132411, XP055955107, ISSN: 0040-4020, DOI: 10.1016/j.tet.2021.132411
DATABASE Registry 14 October 2021 (2021-10-14), ANONYMOUS: "Phenol, 4-(5,6,7,8-tetrahydro-4-methyl-5,8-methanophthalazin-1-yl)- (CA INDEX NAME)", XP093173641, retrieved from STNext Database accession no. 2712574-37-1
DATABASE Registry 11 September 2023 (2023-09-11), ANONYMOUS: " INDEX NAME NOT YET ASSIGNED", XP093173643, retrieved from STNext Database accession no. 2974447-49-7
Attorney, Agent or Firm:
CHENGDU HONGQIAO PATENT LAW OFFICE (CN)
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