Title:
BRUSH PRODRUGS AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2021/076821
Kind Code:
A3
Abstract:
The present disclosure provides, in some aspects, macromonomers of Formula (I), and salts thereof; methods of preparing the macromonomers, and salts thereof; Brush prodrugs (polymers); methods of preparing the Brush prodrugs; compounds of Formula (II); conjugates of Formula (III), and salts thereof; pharmaceutical compositions comprising a Brush prodrug, or a conjugate or a salt thereof; kits comprising: a macromonomer or a salt thereof, a Brush prodrug, a compound, a conjugate or a salt thereof, or a pharmaceutical composition; methods of using the Brush prodrugs, or conjugates or salts thereof; and uses of the Brush prodrugs, and conjugates or salts thereof. These chemical entities may be useful in delivering pharmaceutical agents to a subject or cell.
Inventors:
JOHNSON JEREMIAH (US)
JIANG YIVAN (US)
NGUYEN HUNG (US)
JIANG YIVAN (US)
NGUYEN HUNG (US)
Application Number:
PCT/US2020/055862
Publication Date:
July 01, 2021
Filing Date:
October 15, 2020
Export Citation:
Assignee:
MASSACHUSETTS INST TECHNOLOGY (US)
International Classes:
C08G61/08; A61K47/54; A61K47/59; A61K47/60; C08L65/00
Domestic Patent References:
| WO2019006426A2 | 2019-01-03 | |||
| WO2018149359A1 | 2018-08-23 | |||
| WO2001032652A2 | 2001-05-10 | |||
| WO2011084846A1 | 2011-07-14 | |||
| WO2014004884A1 | 2014-01-03 |
Foreign References:
| EP3315126A1 | 2018-05-02 | |||
| DE2263509A1 | 1974-07-04 | |||
| US20110166128A1 | 2011-07-07 |
Other References:
OHWADA JUN ET AL: "Design, synthesis and antifungal activity of a novel water soluble prodrug of antifungal triazole", BIORGANIC & MEDICINAL CHEMISTRY LETTERS, ELSEVIER, AMSTERDAM , NL, vol. 13, no. 2, 20 January 2003 (2003-01-20), pages 191 - 196, XP002390172, ISSN: 0960-894X, DOI: 10.1016/S0960-894X(02)00892-2
Attorney, Agent or Firm:
ZHANG, William, Wei et al. (US)
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