Title:
BULLEYACONITINE D CRYSTAL AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2020/186961
Kind Code:
A1
Abstract:
Disclosed in the present invention are a bulleyaconitine D crystal and a preparation method therefor. Figure 1 shows an X-ray powder diffraction spectrum of the crystal according to the present invention, the spectrum being measured with Cu-K alpha ray. The bulleyaconitine D crystal is prepared by an anti-solvent process with isopropanol, anisole, 1,4-dioxane or methylbenzene acting as a positive solvent and n-heptane as a negative solvent. The preparation process is simple, and the prepared crystal has a high purity. Upon characterization via XRD, DSC, TGA and 1HNMR, the crystal is determined as D crystal type. Stability test shows that the prepared bulleyaconitine crystal is well stable to light, damp and heat.
Inventors:
WU QIONGFEN (CN)
LI BIAO (CN)
LI BIAO (CN)
Application Number:
PCT/CN2020/076155
Publication Date:
September 24, 2020
Filing Date:
February 21, 2020
Export Citation:
Assignee:
YUNNAN HAOPY PHARMACEUTICALS LTD (CN)
International Classes:
A61P19/02; C07D221/22; A61P19/08; A61P21/00; A61P29/00; A61P35/00
Foreign References:
| CN109734664A | 2019-05-10 | |||
| CN101830849A | 2010-09-15 | |||
| CN102775349A | 2012-11-14 | |||
| CN102924376A | 2013-02-13 | |||
| CN104326981A | 2015-02-04 | |||
| CN101555227A | 2009-10-14 |
Other References:
YUAN, MEI ET AL.: "Chemical Constituents of Aconitum bulleyanum", JOURNAL OF CHINESE MEDICINAL MATERIALS, vol. 36, no. 6, 30 June 2013 (2013-06-30), DOI: 20200516170321X
Attorney, Agent or Firm:
UNITALEN ATTORNEYS AT LAW (CN)
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